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. 2022 Aug 24;38(20):4771–4781. doi: 10.1093/bioinformatics/btac578

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5. — Inter-tissue communication: example of a multi-tissue system with inter-tissue edges indicating hormonal signaling. BioEmbedS predictions for different hormones are enriched for the indicated diseases (top two are shown, along with disease enrichment P-values). Shown alongside each tissue–tissue link are examples of known disease genes that are also genes we predicted for a hormone (with darker-shade black marking the genes in HGv1 dataset, and lighter-shade red the novel out-of-HGv1 genes). The hormones shown may have other source→target tissue pairs besides the tissue pair shown here (A color version of this figure appears in the online version of this article.)