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. 2022 Sep 21;27(19):6196. doi: 10.3390/molecules27196196

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MALDI-MSI molecular pictures obtained by MALDI tandem mass spectrometry imaging for in situ identification of proteins: (a) Human visual cortex, myelin basic protein (red), neuromodulin (green), and hemoglobinβ (blue), MALDI-LTQ-Orbitrap instrument [75]; (b) rat small intestine, endogenous protein biomarkers in lamina propria (green), epithelium (blue), and submucosal layer (red), MALDI-ToF/ToF instrument [78]; (c) mouse model glioblastoma 60S ribosomal protein L34, MALDI-ToF/ToF instruments [83]; (d) AD hippocampal section, MUC19 isoform 5 (green), MALDI-ToF/TOF instrument [76]; (e) mouse pituitary gland, anterior lobe (green), vasopressin (red), γ-MSH (blue), MALDI-LTQ-Orbitrap [82]; (f) human articular cartilage, fibronectin distribution [77]; (g) Libechov minipig skin, normal skin, MALDI-ToF/ToF [81]. Reprinted and adapted with permission from Neagu A.-N., 2019. Proteome Imaging: [28].