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JND4135 displays TRK kinase inhibitory activities against both wild-type (WT) and resistant mutation. (A) structure of JND4135; and representative graphs of kinase inhibitory activities of JND4135 against TRKA (B), TRKB (C), TRKC (D) and TRKA-G667C (E). All kinase inhibitory assays included at least two independent experiments.
