Table 4.
Predictions regarding the metabolism of the stereoisomers of triticonazole (TTZ): CYP—cytochrome, s—substrate, i—inhibitor.
Stereoisomer | CYP 1A2 s |
CYP 1A2 i |
CYP 2C19 s |
CYP 2C19 i |
CYP 2C9 s |
CYP 2C9 i |
CYP 2D6 s |
CYP2 CD6 i |
CYP 3A4 s |
CYP 3A4 i |
---|---|---|---|---|---|---|---|---|---|---|
(R)-TTZ | 0.392 | 0.975 | 0.452 | 0.922 | 0.281 | 0.795 | 0.122 | 0.516 | 0.816 | 0.873 |
(S)-TTZ | 0.481 | 0.976 | 0.484 | 0.894 | 0.104 | 0.564 | 0.066 | 0.414 | 0.718 | 0.790 |