Figure 2. (A) The palmprint segment is a ~100aa region in the active site of the polymerase domain.
Motifs A, B and C are well-conserved; the intervening V1 and V2 regions are more variable. (B) Sequence logos for the five established RdRp-containing ribovirus phyla (Duplorna=Duplornaviricota, etc.) and one for RTs in Artverviricota; a PSSM is constructed corresponding to each logo. (C) Palmscan alignment for NC_009224.1 palmprint showing motifs in canonical ABC order. (D) Alignment for NC_040813.1 withpermuted motifs in CAB order.