Fig. 4. Variation in dose-response slope estimates can be explained by genetic differences among strains.
A) Strain-specific slope estimates for each toxicant are displayed for each strain. Standard errors for each strain- and toxicant-specific slope estimate are indicated by the line extending from each point. B) For each toxicant, the relative steepness of the dose-response slope inferred for that strain compared to the N2 strain is shown. Solid points denote strains with significantly different dose-response slopes (Student’s t-test and subsequent Bonferroni correction with a padj < 0.05, see Methods; Dose-response model estimation), and faded points denote strains without significantly different slopes than the N2 strain. The broad category to which each toxicant belongs is denoted by the strip label for each facet.