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. 2022 Sep 18;14(9):e29297. doi: 10.7759/cureus.29297

Table 1. Neurological symptoms and severity in patients with pre-existing chronic neurological diseases.

Name of disease New symptoms after COVID-19 Hospitalization due to COVID-19 COVID-19 related mortality
Stroke Anosmia, fatigue, dizziness, headache, and myalgia; Dizziness, Headache, Confusion, Altered mental status, Facial droop, Slurred speech, weakness, and Paralysis; Difficulties in memory, poor concentration, visual disturbance, decreased consciousness levels, seizures, delirium, involuntary movements, and ataxia Duration of hospital stay was generally increased.  COVID-19 patients with stroke had higher chances of worse outcomes and more significant mortality than those without. 
Parkinson’s disease (PD) Exaggeration of motor symptoms was more common than non-motor symptoms Increased hospitalization and ICU admission rate among known Parkinson’s patients  Higher mortality rate compared to patients with no neurologic disorders 
Delirium Not related to developing new symptoms. Patients previously diagnosed with dementia are more likely to develop delirium and less likely to exhibit some other COVID-19 symptoms on presentation.  Delirium associated with COVID-19 has been associated with increased mortality. 
Alzheimer’s disease (AD) Neuro-degeneration, Cognitive decline memory deterioration, behavioral changes, orientation abilities, reduced levels of independence, functional decline, and new or deteriorating behavioral disturbances, including aggression, apathy, and depression  People with Alzheimer's Disease are at high risk of contracting COVID-19 and develop worsening outcome  Increased risk of mortality 
Multiple sclerosis (MS) Multiple Sclerosis exacerbation or recrudescence or additional signs not typical of MS Increased in Progressive MS subtype or presence of other comorbidities Not increased
Epilepsy Headache, Myalgia, Delirium, Parageusia, Anosmia, Limb weakness, Distorted mental status after withdrawal of sedatives,  Not increased Increased risk of mortality and sudden unexpected death.