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. 2022 Oct 12;610(7932):575–581. doi: 10.1038/s41586-022-05324-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — (a) Secondary structure and pseudoknot prediction of the ωRNA scaffolds based on covariance model. In CwIsrB/DsIsrB/BbIsrB ωRNAs, SL3 motifs are replaced with unpaired nucleotides. In CsIsrB/K2IsrB/BbIsrB ωRNAs, SL6 motifs are degenerated and SL8 motifs are replaced with unpaired nucleotides. (b) Superposition of AlphaFold (AF) and cryo-EM (EM) structures of DtIsrB. (c) Superposition of AlphaFold structures of six IsrB orthologs. CwIsrB/DsIsrB have β-hairpin and loop insertions in the RuvC domain and RECL, respectively.