Figure 1.
Role of OmpR in A. baumannii virulence assessed in thigh and septicaemia mouse infection models.
A) and B) Neutropenic CD-1 male mice (12 per group) were infected using thigh injection of 107 cfu of AB5075 wildtype (black) or AB5075 ΔompR mutant (white) and 4 animals per group were sacrificed at 2, 24 and 48 hours post infection for bacterial titers determination in A) thigh and B) blood. Mortality was observed in the wildtype group at 24 and 48 hours enabling bacterial titers analysis on only 3 and 1 animal, respectively. Unpaired t-test, *P-value < 0.05. C) Immunocompetent C57BL6J male mice (10 per group) were infected with intravenous injection of 5 × 107 cfu of HUMC1 wildtype (black) or HUMC1 ΔompR mutant (white) and mice survival was monitored for 7 days. Log-rank (Mantel-Cox) test, *P-value < 0.05.