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. 2022 May 3;17(11):1513–1534. doi: 10.1080/15592294.2022.2069386

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — The landscape of genes differentially expressed in livers of healthy rats and HCC rats, as measured by RNA sequencing. (a) A chromosomal map of differentially expressed genes in livers of rats exposed to a choline-deficient diet (CDAA) as compared to healthy rats on a choline-sufficient diet (CSAA). (b) Functional analysis of genes differentially expressed in livers of CDAA vs. CSAA rats, using Gene ontology (in green) and KEGG pathway (in Orange) analyses. (c) Detailed analysis of metabolism-related pathways and corresponding genes that are downregulated (blue) or upregulated (red) within a given pathway in CDAA rats vs. CSAA rats based on RNA-seq. Categories with downregulated or upregulated genes are marked in blue and red, respectively. Grey boxes indicate categories with genes both upregulated and downregulated.