Table 1. Demographic and Clinical Characteristics of Participants in a Study of Viral Shedding 1 Year Following First-Episode Genital Herpes Simplex Virus Type 1 (HSV-1) Infection.
| Baseline characteristic | No. (%) | |
|---|---|---|
| All enrolled (n = 82) | Completed 12-mo follow-up (n = 64) | |
| Age, median (range), y | 26 (16-64) | 26 (16-64) |
| Age ≥26 y | 42 (51.2) | 33 (51.6) |
| Sex | ||
| Women | 54 (65.9) | 43 (67.2) |
| Men | 28 (34.2) | 21 (32.8) |
| Racea | ||
| American Indian/Alaska Native | 0 | 0 |
| Asian | 2 (2.4) | 1 (1.6) |
| Black | 1 (1.2) | 0 |
| Native Hawaiian/Pacific Islander | 0 | 0 |
| White | 66 (80.5) | 53 (82.8) |
| More than 1 option | 10 (12.2) | 8 (12.5) |
| Other | 3 (3.7) | 2 (3.1) |
| Acquisition typeb | ||
| Primaryc | 42 (51.2) | 35 (54.7) |
| Nonprimaryd | 23 (28.1) | 17 (26.7) |
| Unknowne | 17 (20.7) | 12 (18.8) |
| Time since genital HSV acquisition if known, median (IQR), d | 25 (16-42) [n = 82] | 24 (16-59) [n = 64] |
| History of oral HSVf | 10 (12.2)g | 5 (8.3) |
| Days since oral HSV acquisition if known, median (range) | 765 (54-7538) [n = 11] | 65 (54-6059) [n = 6] |
| Method for genital HSV-1 diagnosis | ||
| Only polymerase chain reaction | 28 (34.2) | |
| Only culture | 40 (48.8) | |
| Polymerase chain reaction and culture | 14 (17.1) | |
| No. of sexual partners in past 4 wk, median (range) | 1 (0-6) [n = 75] | 1 (0-6) [n = 61] |
Selected by the participant from a closed list of options that included “other.”
Based on HSV serostatus using the HSV Western Blot at screening visit.
Primary defined as HSV-1 seronegative or HSV-1 indeterminate at first blood draw or increasing antibody over time.
Nonprimary defined as HSV-1 seropositive with first blood sample drawn <42 days after symptom onset.
Unknown defined as HSV-1 seropositive with first blood sample drawn ≥42 days after symptom onset or seroconversion not observed.
Oral HSV was defined as self-reported history of symptoms consistent with oral HSV infection.
Three participants with primary HSV-1 reported history of oral HSV. Two participants had oral HSV symptoms with first-episode genital HSV-1. One participant reported a distant prior history of oral HSV symptoms; this participant had clear evidence of HSV-1 acquisition at the time of first-episode genital HSV-1 based on HSV serologic response, and thus was classified as having primary HSV-1.