FIG 8.

Summary. (1) Infection with M. tuberculosis induces the expression of HIF-1-regulated genes after in BMM. These genes mediate the metabolic switch and macrophage activation required to control the intracellular bacterial infection. (2) During DM, high levels of glucose and reactive carbonyl compounds hamper the expression of HIF-1-regulated genes and in turn impair the control of intracellular M. tuberculosis in BMM. (3) Treatment with the hypoxia mimic deferoxamine (DFO) increased immunometabolic responses in infected BMMs and in the lungs of M. tuberculosis-infected mice. DFO treatment reduced the M. tuberculosis titers in BMM treated or not with IFN-γ. Treatment with DFO restored HIF-1-regulated responses to infection and improved M. tuberculosis control in MGO and high-glucose-treated BMM.