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[Preprint]. 2022 Oct 20:2022.10.19.512891. [Version 1] doi: 10.1101/2022.10.19.512891

Figure 1: Omicron subvariants, especially BQ.1, BQ.1.1, and BA.2.75.2, exhibit strong neutralization resistance.

Figure 1:

(A) Displayed is a schematic of SARS-CoV-2 Omicron subvariant evolution indicating the mutations acquired by the BA.4.6, BF.7, BQ.1, BQ.1.1, and BA.2.75.2 subvariants. (B-C) Infectivity of lentivirus pseudotyped with the indicated S constructs in HEK293T-ACE2 cells, n = 3 (B), or lung-derived CaLu-3 cells, n = 3 (C). Bars represent means +/− standard error. Significance relative to D614G was determined by one-way ANOVA with Bonferroni’s multiple testing correction. P values are represented as ns for p ≥ 0.05, *p < 0.05, and ****p < 0.0001, respectively. (D-F) Neutralizing antibody tiers against lentivirus pseudotyped with S from the indicated SARS-CoV-2 variants were determined for sera from health care workers (HCWs) (n = 15) who received a single homologous monovalent Moderna mRNA-1273 (n =3) or Pfizer/BioNTech BNT162b2 (n =12) mRNA booster vaccination (D), for sera from BA.1-wave hospitalized COVID-19 patients (n = 15) (E), and for sera from BA.4/5-wave SARS-CoV-2 infected Columbus, Ohio first responders and household contacts (n = 20) (F). Bars represent geometric means with 95% confidence intervals. Significance relative to D614G was determined by one-way repeated measures ANOVA with Bonferroni’s multiple testing correction. P values are displayed as ns for p ≥ 0.05, *p < 0.05, **p < 0.01, and ****p < 0.0001.