Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 12;610(7933):796–803. doi: 10.1038/s41586-022-05314-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 9 — a, A TMC-1 protomer in the E conformation (blue) and the C conformation (green), superposed based on backbone alpha-carbon atoms, highlighting conformational changes in TMC-1, as well as CALM-1 and TMIE. The axis of rotation is shown as a red bar and arrows indicate the direction of rotation from the C to the E state. b, Membrane thickness in the C conformation calculated from the last 500 ns of the atomistic MD trajectories, averaged over all the three simulation replicas. Heatmaps corresponding to the thickness of extracellular and cytoplasmic leaflets are shown in left and right panels, respectively.