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. 2022 Oct 10;14(10):2156. doi: 10.3390/pharmaceutics14102156

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A–D) MRI images and median values of the decreases in T₁, T₂, and T₁ × T₂ weighted images in relation to the background signal for old clots, fresh clots, and blood incubated with KCREKA-NPs, PEG-NPs, or PBS. (E) Detailed images of the blood clots with different aging times. * p < 0.05, **** p < 0.0001 using one way ANOVA followed by Kruskal-Wallis test.