Table 15.
Overview of structural stability of co-crystals upon storage in diverse conditions.
| # | Co-Crystal | XRD Interpretation | Storage Time (Days) | Storage Conditions * | Ref. |
|---|---|---|---|---|---|
| 1C | Nicotinamide-L-(+)-ascorbic acid | Without changes in peaks → chemically stable | 180 | At shelf | [66] |
| 3C | Ciprofloxacin-thymol | Stable, no changes of crystalline phase | 50 | Open air | [118] |
| 4C | Urea-caffeine | Formation of co-crystal | Within hours | 25 °C, 30% RH | [119] |
| 7C | Paracetamol-trimethylglycine | Physically stable | 90 | 40 and 75% RH | [44] |
* Acronym: RH: relative humidity.