Abstract
Acute COVID-19 symptoms limit daily activities, but little is known about its association with SARS-CoV-2 viral burden. In this exploratory analysis of placebo recipients in the ACTIV-2/A5401 platform trial, we showed that high anterior nasal (AN) RNA levels and detectable plasma RNA were associated with delayed symptom improvement.
Keywords: SARS-CoV-2, COVID-19, Symptom duration, RNA
Contributor Information
Yijia Li, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA USA.
Linda J Harrison, Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA USA.
Kara W Chew, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA USA.
Judy S Currier, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA USA.
David A Wohl, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC USA.
Eric S Daar, Lundquist Institute at Harbor-UCLA Medical Center, Los Angeles, CA USA.
Teresa H Evering, Weill Cornell Medical College, New York, NY USA.
Ryan Wu, Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA USA.
Mark Giganti, Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA USA.
Justin Ritz, Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA USA.
Arzhang Cyrus Javan, National Institutes of Health, Bethesda, MD USA.
Robert Coombs, Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA USA.
Carlee Moser, Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA USA.
Michael D Hughes, Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA USA.
Joseph J Eron, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC USA.
Davey M Smith, Department of Medicine, University of California, San Diego, La Jolla, CA USA.
Jonathan Z Li, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA USA.
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