Retraction of: Shayesteh R Ferdosi, Brett Taylor, Matthew Lee, Nanyun Tang, Sen Peng, Rita Bybee, George Reid, Lauren Hartman, Krystine Garcia-Mansfield, Ritin Sharma, Patrick Pirrotte, Jianhui Ma, Alison D Parisian, Frank Furnari, Harshil D Dhruv, Michael E Berens, PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors, Neuro-Oncology, Volume 24, Issue 11, November 2022, Pages 1857–1868, https://doi.org/10.1093/neuonc/noac067
The authors of this article wish to note that due to an error in the combination index calculation, their report of synergy (Figure 6C and 6D) from the combinations of pevonedistat plus etoposide and pevonedistat plus doxorubicin in M059K and SNU1105 glioma cells was false. TOP2A inhibitors combined with MLN4924 are not synergistic in PTENnull cells.
The title’s declaration that TOP2A inhibition overcomes resistance to MLN4924 is erroneous.
Therefore, although other findings in the publication have proven to be accurate and reproducible, due to this unfortunate error the authors have unanimously requested that the article be fully retracted. The authors apologize to the readers and reviewers of Neuro-Oncology.
As a consequence of this article’s retraction, the corresponding Editorial Commentary is also retracted by the Journal (Goenka A, Cheng SY, Targeting neddylation in cancer, Neuro-Oncology 2022 24(11); 1869–1870. https://doi.org/10.1093/neuonc/noac159
Contributor Information
Shayesteh R Ferdosi, Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Brett Taylor, Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Matthew Lee, Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Nanyun Tang, Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Sen Peng, Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Rita Bybee, Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
George Reid, Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Lauren Hartman, Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Krystine Garcia-Mansfield, Collaborative Center for Translational Mass Spectrometry, The Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Ritin Sharma, Collaborative Center for Translational Mass Spectrometry, The Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Patrick Pirrotte, Collaborative Center for Translational Mass Spectrometry, The Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Jianhui Ma, Ludwig Cancer Research, San Diego Branch, La Jolla, CA 92093, USA.
Alison D Parisian, Ludwig Cancer Research, San Diego Branch, La Jolla, CA 92093, USA.
Frank Furnari, Ludwig Cancer Research, San Diego Branch, La Jolla, CA 92093, USA; Department of Pathology, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
Harshil D Dhruv, Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Michael E Berens, Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, AZ 85004, USA.