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. 2022 Aug 31;611(7934):139–147. doi: 10.1038/s41586-022-05273-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — (a–d) PBMCs were isolated from HD (n = 9), OUT-C (n = 7), or ICU-C (n = 10) patients and analyzed by spectral flow cytometry. (a) Progressive gating strategy for flow cytometry. Label above plot indicated pre-gating population from previous plot. (b) CD19^- ASC frequency of total ASCs. (c) ASC frequency of total B cell-derived cells. (d) Linear regression analysis of log2-transformed DN2 vs ASC frequencies of total B cell-derived cells. (b, c) Statistical significance was determined using ANOVA with Tukey’s multiple-comparisons testing between all groups. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001.