Abstract
Mechanism of Synthetic Retinoid Kills Cancer‐Stem‐Cell‐Like Cells
In article number 2203173, Xing Cao, Ning Wang, Junwei Chen, and co‐workers reveal the mechanism of synthetic retinoid WYC‐209 overcomes the limitation of conventional anticancer drugs by inducing tension‐abrogation mediated chromatin decondensation and DNA damage to kill cancer‐stem‐cell‐like cell tumor repopulating cells. This finding provides a new perspective strategy of lowering cell tension and decondensing chromatin to enhance efficacy of anti‐cancer drugs to abrogate metastasis of cancer stem cell like cells.
