The B abortus
–injected mice develop both acute and
chronic inflammation, with an early rise in hepcidin mRNA.
Compared with saline-injected mice, the B abortus
–
injected mice develop (A) increased SAA-1 mRNA by 3 hours,
peaking at 1 day, and a gradual return to normal by 21 days; (B)
increased hepcidin mRNA, with a peak at 6 hours, a slight but consistent
increase through 7 days, followed by significant decrease at 14 and 28
days; (C) increased serum hepcidin protein at 6 hours; (D) increased
WBCs by 7 days, with partial recovery by 28 days; and (E) hepatic
perivascular infiltration of inflammatory cells by 7 days. (A-B) Means
± standard error, with each B abortus
–
treated group referenced to contemporaneous saline-treated group.
(C-D) Means ± SD, *P < .05 and
**P < .001 by Student
t test or Mann-Whitney U test.