The authors of “Tyrosine Phosphorylation of Sprouty Proteins Regulates Their Ability to Inhibit Growth Factor Signaling: A Dual Feedback Loop” (Mol Biol Cell. 15, 2176–2188; originally published in MBoC In Press as doi.org/10.1091/mbc.e03-07-0503, 5 Mar 2004) have detected errors in a number of figure subpanels, specifically 1B, 2B, 3B, 5B, 5C, 6D, and 8D, of their article and are unable to correct them in the absence of the original data. While the key findings of this study were confirmed by other experiments presented in subpanels within the article and by other research groups, the authors wish to retract their article and regret any inconvenience caused by these mistakes.