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. 2022 Nov 4;11:e68745. doi: 10.7554/eLife.68745

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© 2022, Kim, Jimenez et al

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Figure 3. — A strong recruitment elements on the X-chromosome (rex) site with four motifs in the same orientation acts as a topologically associating domain (TAD) boundary on the X. The 358-bp rex-8 was inserted in two orientations at the same site on X-chromosome. Hi-C interactions surrounding the insertion sites along with the insulation score (black) and its subtraction to that of wild type (red), and DPY-27 ChIP-seq are plotted. A dip in the insulation score coincides with enrichment of DPY-27 ChIP (purple arrow) and supports barrier activity. Log2ratio plot highlights the lack of noticeable Hi-C difference between insertion of two different orientations.