Figure 7. Model of condensin dosage compensation (DC) recruitment and spreading forming loop-anchored topologically associating domains (TADs).

Shown are three conceptually distinct features that contribute to TAD formation in C. elegans dosage compensation complex (DCC) system. The model as a group contains the following properties: (i) rex is a bidirectional barrier, (ii) rex is a loading site, (iii) rex can activate/enhance weaker ‘secondary loading sites,’ (iv) condensin DC is a one-sided loop extruder, and (v) condensin DC’s loop-anchor is prone to displacement.