Table 3.
Incidence rates for each AESI and negative control event by nursing home residence status among CMS Medicare beneficiaries aged 65+ years in 2019.
| AESI or negative control | All Medicare beneficiaries IR per 100,000 PY (95 % CI) |
Nursing home IR per 100,000 PY (95 % CI) |
Non-nursing home IR per 100,000 PY (95 % CI) |
IRR comparing nursing home vs non-nursing home (95 % CI) |
|---|---|---|---|---|
| AMI | 1,297.48 (1,293.01–1,301.97) |
3,037.00 (2,991.55–3,082.96) |
1,257.34 (1,252.88–1,261.80) |
2.42 (2.38–2.45) |
| Anaphylaxis | 10.57 (10.18–10.96) |
7.09 (5.15–9.52) |
10.65 (10.26–11.05) |
0.67 (0.48–0.90) |
| Appendicitis | 80.05 (78.95–81.16) |
50.74 (45.09–56.89) |
80.74 (79.62–81.87) |
0.63 (0.56–0.71) |
| Bell’s palsy | 215.42 (213.64–217.21) |
288.54 (275.06–302.50) |
213.71 (211.92–215.51) |
1.35 (1.29–1.42) |
| DVT | 1,330.99 (1,326.43–1,335.55) |
3,732.56 (3,681.22–3,784.43) |
1,277.11 (1,272.6–1,281.63) |
2.92 (2.88–2.96) |
| DIC | 36.91 (36.17–37.67) |
103.54 (95.41–112.18) |
35.35 (34.61–36.10) |
2.93 (2.69–3.18) |
| ENC | 9.82 (9.44–10.21) |
18.55 (15.26–22.34) |
9.62 (9.24–10.00) |
1.93 (1.58–2.33) |
| GBS | 4.63 (4.36–4.90) |
2.77 (1.58–4.50) |
4.67 (4.40–4.95) |
0.59 (0.34–0.97) |
| HS | 205.26 (203.49–207.04) |
416.60 (400.07–433.63) |
200.32 (198.55–202.09) |
2.08 (2.00–2.17) |
| ITP | 90.21 89.03–91.39) |
122.14 (113.28–131.50) |
89.45 (88.28–90.65) |
1.37 (1.26–1.47) |
| Myocarditis/pericarditis | 88.09 (86.94–89.26) |
155.04 (145.05–165.55) |
86.52 (85.36–87.69) |
1.79 (1.67–1.92) |
| Narcolepsy | 37.71 (36.96–38.48) |
73.33 (66.51–80.66) |
36.88 (36.12–37.65) |
1.99 (1.80–2.19) |
| NHS | 842.83 (839.23–846.44) |
1,757.09 (1,722.59–1,792.11) |
821.80 (818.2–825.40) |
2.14 (2.10–2.18) |
| PE | 755.10 (751.69–758.53) |
1,447.10 (1,415.82–1,478.88) |
739.06 (735.65–742.49) |
1.96 (1.91–2.00) |
| TM | 3.38 (3.15–3.61) |
7.62 (5.53–10.22) |
3.28 (3.06–3.51) |
2.32 (1.67–3.15) |
| Unusual site TTS | 12.49 (12.06–12.93) |
13.54 (10.53–17.13) |
12.47 (12.03–12.92) |
1.09 (0.84–1.38) |
| Common site TTS | 362.30 (359.95–364.67) |
760.53 (736.67–784.96) |
354.12 (351.77–356.48) |
2.15 (2.08–2.22) |
| CD, in thousandsa | 8.91 (8.89–8.92) |
5.65 (5.58–5.71) |
8.99 (8.97–9.00) |
2.32 (1.67–3.15) |
| HTN, in thousandsa | 26.55 (26.52–26.59) |
59.02 (58.42–59.63) |
26.28 (26.24–26.31) |
1.09 (0.84–1.38) |
| WCV, in thousandsa | 47.88 (47.85–47.91) |
16.79 (16.68–16.90) |
48.74 (48.71–48.77) |
0.34 (0.34–0.35) |
Abbreviations: AESI, adverse event of special interest; AMI, acute myocardial infarction; CD, colonic diverticulitis; CI, confidence interval; CMS, Centers for Medicare & Medicaid Services; DIC, disseminated intravascular coagulation; DVT, deep vein thrombosis; ENC, encephalitis/encephalomyelitis; GBS, Guillain-Barré syndrome; HS, hemorrhagic stroke; HTN, hypertension; IR, incidence rate; IRR, incidence rate ratio; ITP, immune thrombocytopenia; NHS, non-hemorrhagic stroke; PE, pulmonary embolism; PY, person-years; TM, transverse myelitis; TTS, thrombosis with thrombocytopenia syndrome; WCV, well-care visit.
Incidence rates of negative control events are reported in thousands (e.g., a value of 1 corresponds to a rate of 1,000 per 100,000 person-years).