Table 3. Studies associated with cffDNA analysis for trisomies.

Article/ study	Sample size	Result
Bogaert et al. [21]	153,575 pregnant females	Positive predictive value of   Down syndrome: 92.4%, Edward syndrome: 84.6%, Patau syndrome: 43.9%
Kostenko et al. [22]	101,899 pregnant females	Detection rate being Patau syndrome: 94%, Down syndrome: 100%, Edward syndrome: 97%
Verde et al. [23]	36,456 pregnant females	Sensitivity Down syndrome: 99.2%, Edward syndrome: 91.2%, Patau syndrome: 84.4%