Figure 2. Role of CRP in the pathogenesis of cardiovascular diseases.

CRP: C - reactive protein, CVD: Cardiovascular diseases, DIC: Disseminated intravascular coagulation, ERK: Extracellular signal-regulated kinase, ICAM-1: Intercellular adhesion molecule, IL-8: Interleukin-8, LDL: MCP-1: Monocyte chemoattractant protein-1, MEK: Mitogen-activated protein kinase kinase, NO: Nitrous oxide, PAI-1: Plasminogen activator inhibitor-1, PI3K-Akt: Phosphatidylinositol-3-kinase- Protein kinase B, Raf-1: Serine/threonine kinase, Ras: GTPase protein, TG: Triglycerides, TGF-β: Transforming growth factor-β,VCAM-1: Vascular cell adhesion molecule.

Image source: Luan and Yao, 2018 [40] (Open access)