Table 2.
List of the differentially expressed proteins according to the fibrosis stages (F0–2 vs. F3–4).
| SEQ | Protein | N | Coef | Logistic Regression p-Value |
Wilcoxon Test p-Value |
Fold Change | F0–2 (N = 31) |
F3–4 (N = 33) |
|---|---|---|---|---|---|---|---|---|
| 1 | CD68 | 64 | 0.00650 | 2.78 × 10−2 | 1.96 × 10−2 | 1.50 | 118.62 | 178.04 |
| 2 | HLA.DR | 64 | 0.02140 | 4.62 × 10−2 | 3.83 × 10−2 | 1.38 | 35.41 | 48.82 |
| 3 | Phospho.c.RAF | 64 | −1.06091 | 4.96 × 10−2 | 4.43 × 10−2 | −1.27 | 1.23 | 0.97 |
| 4 | Cleaved.Caspase.9 | 64 | −0.10881 | 3.22 × 10−2 | 2.59 × 10−2 | −1.28 | 14.62 | 11.46 |
| 5 | CD127 | 64 | −0.48734 | 2.09 × 10−2 | 1.57 × 10−2 | −1.29 | 3.77 | 2.93 |
| 6 | ARG1 | 64 | −0.00693 | 4.21 × 10−2 | 3.52 × 10−2 | −1.31 | 200.13 | 152.53 |
| 7 | Beta.2.microglobulin | 64 | −0.11174 | 2.84 × 10−2 | 2.32 × 10−2 | −1.31 | 12.67 | 9.63 |
| 8 | X4.1BB | 64 | −1.28366 | 1.77 × 10−2 | 1.22 × 10−2 | −1.35 | 1.41 | 1.04 |
| 9 | LAG3 | 64 | −0.94575 | 4.71 × 10−2 | 4.05 × 10−2 | −1.37 | 1.17 | 0.85 |
| 10 | B7.H3 | 64 | −0.07086 | 3.41 × 10−2 | 2.50 × 10−2 | −1.46 | 19.21 | 13.17 |
| 11 | VISTA | 64 | −0.41498 | 2.02 × 10−2 | 1.27 × 10−2 | −1.50 | 3.58 | 2.39 |
| 12 | Tim.3 | 64 | −0.50608 | 1.91 × 10−3 | 3.18 × 10−4 | −1.51 | 5.56 | 3.68 |
| 13 | pan.RAS | 64 | −1.75375 | 1.46 × 10−3 | 6.02 × 10−4 | −1.70 | 1.69 | 1.00 |
| 14 | OX40L | 64 | −1.13933 | 8.75 × 10−3 | 1.76 × 10−3 | −2.60 | 2.69 | 1.03 |
| 15 | STING | 64 | −0.09585 | 8.76 × 10−3 | 4.27 × 10−3 | −2.65 | 19.19 | 7.26 |
Abbreviation: CD68, cluster of differentiation 68; HLA.DR, human leukocyte antigen-DR isotype; ARG1, arginase 1; LAG3, lymphocyte activation gene 3; B7.H3, B7 homolog 3 protein; VISTA, V-domain IgG suppressor of T cell activation; Tim.3, T cell immunoglobulin and mucin domain-containing protein 3; OX40L, OX40 ligand; STING, stimulator of interferon genes.