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. 2022 Nov 1;27(21):7437. doi: 10.3390/molecules27217437

Table 1.

Inhibition of FA derivatives 16, and compounds 15 and 16 against hChEs and hMAOs.

Compound hAChE hBChE hMAO-A hMAO-B
% @ 10 µM IC50 (µM) % @ 10 µM
graphic file with name molecules-27-07437-i001.jpg 51 ± 2 18 ± 4 20 ± 5 26 ± 5
graphic file with name molecules-27-07437-i002.jpg 42 ± 2 ni 15 ± 5 21 ± 4
graphic file with name molecules-27-07437-i003.jpg 6.58 ± 0.27 ni 5 ± 3 11 ± 4
graphic file with name molecules-27-07437-i004.jpg 2.63 ± 0.57 38 ± 2 26 ± 5 20 ± 4
graphic file with name molecules-27-07437-i005.jpg 41 ± 4 ni 23 ± 6 16 ± 5
graphic file with name molecules-27-07437-i006.jpg 7.20 ± 0.54 ni ni ni
graphic file with name molecules-27-07437-i007.jpg 58 ± 5 ni 11 ± 3 16 ± 3
graphic file with name molecules-27-07437-i008.jpg 40 ± 4 ni 14 ± 4 16 ± 5

ni, no inhibition.