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Possible pathomechanisms explaining elevated plasma vitamin B12 in patients with some cancers. Haptocorrin (TCN1) is overexpressed in cancer tissues and this expression is related to the stage of tumor, apoptosis, and inflammation processes. The short-living neutrophils originate from the bone marrow. The neutrophils express high level of TCN1 and are engaged in the body defense against cancer tumor. Neutrophils-originated-TCN1 may capture B12 and explain its retention in plasma.
