Figure 6.

Effects of various metal chelators on the induction of apoptosis by curcumin in four distinct cancer cell lines. As depicted in the image, PC3, LNCaP, DU145, and C42B cancer cells were treated with 25 µM of curcumin alone or in the presence of the copper chelator neocuproine (Neo), the iron chelator desferrioxamine mesylate (DM), or the zinc chelator histidine (His). The concentration of metal chelators utilized was 50 µM. After 72 h of treatment as specified in Section 2, ELISA was performed. The stated values are the ±S.E.M. of three separate experiments. * p value < 0.05 in comparison to the control group.