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. 2022 Nov 15;228(1):152302. doi: 10.1016/j.imbio.2022.152302

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Fig. 5 — Structures of SARS-CoV-2 non-structural proteins. (a) The upper panel shows the domains organization of SARS-CoV-2 nsp1; NTD (N-terminal domain) and CTD (C-terminal domain). The middle panel shows the cartoon and surface representation of nsp1 CTD in complex with the host ribosomal 40S subunit (PDB: 7K7P). The lower panel shows binding residues of nsp1 CTD with the 40S ribosomal subunit. (b) The upper panel shows the domain organization of SARS-CoV-2 nsp3. The lower-panel shows the cartoon representation of functional domains. The conserved zinc-binding motifs are highlighted in the SARS-CoV-2 nsp3 structure (PDB: 6WRH). The coordinate details of the zinc-binding residues are shown in stick representation. (c) Schematic representation of domain features of SARS-CoV-2 nsp5 (Mpro) in the upper panel. The lower panel shows the cartoon representation of Mpro (PDB: 6YB7) with magnified views on the two zinc-finger motifs. The domain I, domain II, and domain III are colored with violet, lemon, and red, respectively. Residues involved in zinc-coordination are shown in sticks. (d) The cartoon and surface representation of crystal structure of dimeric SARS-CoV-2 nsp9 (PDB: 6WXD). Predicted RNA binding sites on the surface of one face of the SARS-CoV-2 nsp9 dimer are identified with black arrows: between β7 and α1 (L60), β2 and β3 (L23), and β4 and β5 (L45). (e) The upper panel shows the domain organization of SARS-CoV-2 nsp13. Here, the zinc-binding domain (ZBD), stalk domain, 1B, 1A, and 2A are colored with violet, cyan, green, blue, and red, respectively. The lower panel shows a cartoon and surface representation of the crystal structure of SARS-CoV-2 nsp13 (PDB: 7NIO). Magnified views on the three zinc-finger motifs in SARS-CoV-2 helicase apo form. Residues involved in zinc-coordination are shown in sticks. (f) The upper panel shows the primary structure of SARS-CoV-2 nsp15. Here, N-domain, N-terminal domain, middle domain, and endoU domain are colored with blue, lemon, and brown, respectively. The lower panel shows a cartoon and surface representation of the crystal structure of SARS-CoV-2 nsp15 (PDB: 6WLC). The rectangular box shows active sites of the endoU domain.