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. 2022 Nov 15;228(1):152302. doi: 10.1016/j.imbio.2022.152302

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Fig. 8 — Structures of SARS-CoV-2 accessory proteins. (a) The upper panel shows a schematic representation of the domains of SARS-CoV-2 ORF3a protein; N-terminal ectodomain, three transmembrane regions, a cysteine-rich domain, YxxΦ domain, diacidic domain, and C-terminal endodomain. The lower-left panel shows a cartoon and surface representation of cryo-EM structure of dimeric ORF3a (PDB: 6XDC). The lower-right panel shows protein–protein interactions between the A-chain and B-chain of the dimeric structure. (b) The upper panel shows the overall topology of SARS-CoV-2 ORF8. The lower-left panel shows the cartoon and surface representation of the crystal structure of dimeric ORF8 (PDB: 7JTL). The lower-right panel shows detailed protein–protein interactions between the A-chain and B-chain of the dimeric structure.