Dear editor
We acknowledge the effort made by the author to craft the response to our recent publication in infection and drug resistance.1 We are pleased that the author appreciated our work and found the results of the study promising to fight antibiotic resistance and resistant superbugs like Klebsiella pneumoniae. In addition to that, the author raised some fair queries regarding the methods and suggested possible explications. For instance, though we have characterized the isolates in the present investigation, we mentioned only the string test as a phenotypic test to characterize the hypervirulent isolates, which served the purpose of the study.2 However, as the authors suggested that mentioning the detailed molecular identification of the hypervirulent strains could be a better procedure. Taking it together, we appreciate the author for valuable suggestions and future directions to decipher the molecular mechanisms involved in the lytic activity of bacteriophage KpnM, which we shall consider in our imminent research plans.3
Disclosure
All the authors reported that there is no conflict of interest in this communication.
References
- 1.Aslam B, Siddique MH, Siddique AB, et al. Distribution of mcr-1 harboring hypervirulent Klebsiella pneumoniae in clinical specimens and lytic activity of bacteriophage KpnM against isolates. Infect Drug Resist. 2022;15:5795–5811. doi: 10.2147/IDR.S374503 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Shon AS, Bajwa RP, Russo TA. Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence. 2013;4(2):107–118. doi: 10.4161/viru.22718 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Aslam B, Arshad MI, Aslam MA, et al. Bacteriophage proteome: insights and potentials of an alternate to antibiotics. Infect Dis Ther. 2021;10(3):1171–1193. doi: 10.1007/s40121-021-00446-2 [DOI] [PMC free article] [PubMed] [Google Scholar]