Table 5.

Significant mediator of the association between drought exposure and weight-for-Age Z-Score^a.

Model	CpG	Nearest gene	ACMEc	ACME P value	ADE d	ADE P value	Proportion mediated	ACME pFDRe
zWeightb	cg03771070	AKAP7	−0.31	<0.01	−0.15	0.41	0.69	<0.01

^acg23311137 (near ATP2C1) is differentially methylated between drought exposed and unexposed siblings (pFDR < 0.01) and is a significant mediator for drought and zTriceps skinfold thickness (ACME −0.2, ACME p = 0.04, proportion mediated −0.2976). However, cg23311137 is non-significant after FDR correction at mediation step (0 of 1 CpG site for drought and triceps skinfold thickness for age are significant after FDR correction at mediation step.); ^bAs shown, 1 out of 1 CpG site is significant after FDR correction at mediation step; ^cACME is indirect effect (average causal mediated effect); ^dADE is average direct effect. ^e P-values were corrected for 16 tests.