Dear Editor, we would like to discuss on “Severe treatment-refractory antibody positive autoimmune autonomic ganglionopathy after mRNA COVID19 vaccination [1].” While autonomic impairment has previously been documented following COVID19 vaccination, this is to our knowledge the first example of antibody-positive AAG in this situation, according to Rowe et al. [1]. In stark contrast to the existing research on idiopathic antibody-positive autoimmune pandysautonomia [1], this case is more severe. Co-morbidity can be challenging to treat, thus it is crucial to look into any potential COVID-19 vaccination concerns [2]. This usually isn't a good alternative if a clinical problem arises following the vaccination. It is crucial to screen out any underlying illnesses or co-morbidities that could potentially lead to a clinical problem before immunization. Patients with SARS-Co-V2 may not be identified because they show no symptoms. The meaning of other sources is ambiguous, and co-morbidity is occasionally mistakenly thought to have a negative effect [3]. Recent studies [4] have also connected underlying genetic variation to recipients' immune responses to the COVID-19 vaccination. Future studies should consider the many genetic background variables.
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Data availability
No data was used for the research described in the article.
References
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Data Availability Statement
No data was used for the research described in the article.