Table 4.

Comparison between severity factors of patients with a co-detection and single HBoV infection

Severity factor	Cases with co-detections (n = 64)	Cases with single HBoV detection (n = 21)	p value
Co-morbidities	48 cases (75%)	13 cases (62%)	0.25
Median length of stay	4 days (IQR 2–6)	3 days (IQR 2–4)	0.11
Respiratory support requirement	53 cases (83%)	19 cases (91%)	0.4
Nasal oxygen cannula	39 (74%)	17* (90%)
High-flow nasal cannula oxygen	8 (14%)	1 (5%)
Non-invasive mechanical ventilation	4 (7%)	1 (5%)
Invasive mechanical ventilation	2 (4%)†	0
Median length of respiratory support	3 days (IQR 2–5)	1 day (IQR 1–3)	0.012
PICU admission	6 cases	1 case	–
Median length of stay at PICU	5 days (IQR 3–17)	4 days	0.6
Treatment with bronchodilators	56 cases (87%)	18 cases (86%)	0.8
Antibiotic treatment	29 cases (45%)	9 cases (43%)	0.6

Only those patients manifesting a LRTI (85) have been taken into consideration for this comparison. Cases are differentiated whether there were co-detections found or not along the HBoV laboratory-confirmation, and the statistical significance was calculated for each item

IQR interquartile range, PICU paediatric intensive care unit

*One had a previous pneumopathy, requiring conventional oxygen at home

†Two episodes of the same patient, a child with a previous pneumopathy and receiving mechanical ventilation at home through tracheotomy