Appendix 3—figure 3. Comparison of our main results about the allele dynamics with the corresponding results of the full model simulations.

The results shown are based on 500 full model simulations with the parameters of the non-Lande case used in the main text (see section on Simulations and resources). We calculate the relative contribution from each effect size bin (between the gray gridlines) by dividing the contribution of all alleles in the bin by the mutation rate per generation corresponding to that bin. We show the relative phenotypic contribution per unit mutational input of alleles as a function of effect size squared (A and C) and initial MAF (B and D) in the rapid (top) and equilibration (bottom) phases.