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. 2022 Oct 23;12(11):1546. doi: 10.3390/biom12111546

Figure 7.

Figure 7

TAX attenuates the ISO-induced myocardial apoptosis in mice. (A) Images of the microscopic field of IHC labeled cardiac sections from control and TAX-treated mice, showing obvious expression of Bcl-2 within the myocardial fibers (arrows), along with mild expression of myocardial Bax and caspase-3 (arrows); ISO-injected mice demonstrating a noticeable reduction in the myocardial level of Bcl-2 (arrows), along with remarkably increased myocardial Bax and caspase-3 (arrows); and mice treated with 25 and 50 mg/kg TAX before ISO injection demonstrating a noticeable increase in myocardial expression of Bcl-2 (arrows), along with a marked reduction in the expression of Bax and caspase-3 in the myocardial tissues (arrows). (IHC, X200, Scale bar = 50 µm). (B–D) Analysis of the relative intensities of the images of IHC-labeled myocardial Bcl-2, Bax, and caspase-3, showing a significantly increased Bcl-2 and decreased Bax and caspase-3 in mice pre-treated with both doses of TAX. Data are expressed as mean ± SEM, (n = 6). Here, a indicates significant (p < 0.05) vs. control, while b indicates significant (p < 0.05) vs. ISO.