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. 2022 Oct 23;12(11):1546. doi: 10.3390/biom12111546

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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TAX upregulates Nrf2/HO-1 signaling in ISO-administrated mice. Images of the microscopic field of IHC labeled cardiac sections from (A) control and (B) TAX-treated mice, indicating obvious cytoplasmic immunostaining of Nrf2 within the myocardial fibers (arrows); (C) ISO-administered mice showing focal myocardial expression of Nrf2 (arrows); (D) ISO-injected mice pre-treated with 25 mg TAX demonstrating increased Nrf2 expression within the myocardial fibers (arrows); and (E) ISO-injected mice pre-treated with 50 mg demonstrating a noticeable rise in the myocardial expression of Nrf2 (arrows) (IHC, X200, Scale bar = 50 µm). (F) Analysis of the relative intensities of the images of IHC labeled myocardial Nrf2 demonstrating a significant increase in Nrf2 in the myocardium of mice treated with both doses of TAX before ISO injection. (G) TAX significantly attenuates myocardial levels of HO-1 in ISO-injected mice. Data are expressed as mean ± SEM, (n = 6). Here, a indicates significant (p < 0.05) vs. control, while b indicates significant (p < 0.05) vs. ISO.