Table 6.
Validity (AUC, sensitivity, specificity) for different parameters to discriminate severe group (n = 60) from moderate group (n = 60).
| AUC | p | 95% C.I | Cutoff | Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|---|---|---|---|
| A2M-AS1 | 0.934 | <0.001 * | 0.892–0.976 | ≤0.98 | 98.33 | 75.0 | 79.7 | 97.8 |
| FLVCR1 | 0.653 | 0.001 * | 0.585–0.780 | ≤0.82 | 63.33 | 61.67 | 62.3 | 62.7 |
| DBH-AS1 | 0.802 | <0.001 * | 0.715–0.890 | >9 | 75.0 | 81.67 | 80.4 | 76.6 |
| FLVCR1-DT | 0.771 | <0.001 * | 0.683–0.860 | >8.6 | 71.67 | 70.0 | 70.5 | 71.2 |
| NCBP2AS2-1 | 0.951 | <0.001 * | 0.902–1.0 | >3.55 | 91.67 | 85.0 | 85.9 | 91.1 |
AUC: Area under the curve. p value: Probability value. CI: Confidence interval. NPV: Negative predictive value. PPV: Positive predictive value. *: Statistically significant at p ≤ 0.05.