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HSP90 inhibition downregulates CD4 and CD8 surface expression. HSP90 inhibitor downregulates surface expression of CD4 (A) and CD8 (B). T cells were incubated for 4 days with allogeneic mo-DCs in the presence or absence of 0.1 µM geldanamycin (GA). (C) Representative flow cytometry plots showing downregulation of CD4 and CD8 molecules on the surface of T cells in response to GA in MLR. Data are presented as mean ± SEM. * p < 0.05, ** p < 0.01.
