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. 2022 Nov 1;11(11):1284. doi: 10.3390/pathogens11111284

Figure 6.

Figure 6

Antigenic variations identified in the H7 HA proteins in the 2022 Mexican H7N3 HPAIV. (A) The known antigenic sites are color-coded and are shown in the globular head of H7 HA. (B) SeqLogo analysis of amino acid substitutions at known antigenic sites of the HA protein against HA proteins of the inactivated vaccine strain, A/chicken/Guanajuato/CPA-07669-16-VS/2016 (accession no. MH158233), recombinant vaccine strain, A/chicken/Mexico/Jalisco-CPA-06078-19/2019 (accession no. MN982709). The sequence logo consists of stacks of symbols for the corresponding amino acids at antigenic sites. (C) Substituted antigenic residues are shown in red, compared with antigenic residues of the inactivated vaccine strain. (D) Substituted antigenic residues are shown in red, compared with antigenic residues of the recombinant vaccine strain. The H7 HA crystal structure is manipulated with Chimera and is shown in the surface format, using the structure from A/turkey/Italy/214845/2002 (PDB # 4BSG). Antigenic sites are denoted as follows: yellow, site A; cyan, site B; blue, site C; green, site D; purple, site E.