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. 2022 Nov 8;12(11):1081. doi: 10.3390/metabo12111081

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The potential cross-talk between different factors and biological pathways involved in the development of MAFLD. MAFLD is a complex disease that involves dysregulations in multiple biological pathways, specifically amino acid, arachidonic acid, bile acid and lipid metabolism, which is modulated by interactions between genetic predisposition, metabolic syndromes and environmental factors. Note: acetyl-CoA, acetyl coenzyme A; G6P, glucose 6-phosphate; PFAS, perfluorinated alkyl substances; COXs, cyclooxygenases; LOXs, lipoxygenases; PL, phospholipase; PNPLA3, patatin-like phospholipase domain-containing protein 3 gene; TM6SF2, transmembrane 6 superfamily member 2 gene; GCKR, glucokinase regulatory protein gene. Partially inspired by Masoodi et al. [18]. The mitochondrion and lipid droplets illustrations were adapted (modified with layer and text) from Servier Medical Art. Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/, accessed on 1 October 2022).