Table 1.

Nucleotide substitutions of the ERG11 gene identified in cultures of C. albicans CAF2-1 strain under various conditions. Hot-spot nucleotide mutations are marked in bold; previously identified mutations are marked in italics; mutations that did not result in an amino acid substitution are underlined.

			Concentration of Fluconazole [µg/mL]
			0	0.25	1	4	16
Carbon source	Glucose	8 h	C30T, T819M, T826G, A828T	C30T, A31G, T37A, T819M, T826G, A828T	A105T, C746A, A751T, T826G, A828T, T1558C	A35T, T37A, A797G, T826G, A828T, T1558C	C30A, A31G, T37A, A383C, T826G, A828T, T1470C, T1558C
		14 h	C30T, A35T, T37A, A790G, G791A, G794A	A35T, T37A, A657G, T768A, T826G, A828T, T1470C	A35T, A105T, C746A, T826G, A828T	T33G, A35T, A383C, A750T, T826G, A828T, T1470C, T1558C	T27G, C30T, A34T, A357C, A383C, T826G, A828T, T1470C, T1558C
		24 h	C30W, A31G, T32S, A90G, T92G, T826G, A828T	C30W, A31G, T32S, T822M, G823Y, A824G, T826G, A828T	T33G, A35T, T37A, G673C, T826G, A828T, A1440G, A1516G	A31G, T32S, G791A, G796A, A797G, T826G, A828T, A1516G	C30T, T32S, A35T, T826G, A828T, T1470A, A1516G
	Lactate	8 h	A31G, T32S, T826G, A828T	T32G, T33S, A34T, T37A, C799R, T826G, A828T	C30W, A31G, T32S, T826G, A828T	G29W, A35T, T37A, T826G, A828T, T1470A	C30A, A31S, T36A, T826G, A828T, T1470C
		14 h	T33G, A34T, G791A, A792G, G794A, T826G, A828T	T33G, A34T, T826G, A828T, T1470C	A34T, G673T, T826G, A828T	C30T, A34T, A383C, T826G, A828T, T1470C	T26G, C30T, A383C, A776T, A790G, T826G, A828T
		24 h	A31G, T32S, A790G, T826G, A828T, A1440G, T1470C	C658T, A776T, G794A, T822G, T826G, A828T	A31G, T33G, A793G, T826G, A828T	A31G, T32S, A383C, A780C, A785T, T826G, A828T	G28A, A35T, T36A, A383C, A780C, G796A, A798G, C799A, T826G, A828T, A1551T