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. 2022 Jun 21;30(6):2477–2488. doi: 10.1007/s10787-022-01010-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A photomicrograph of brain tissue section of rat from control and ALCL₃-treated rats. Cilostazol alleviated the neurodegenerative pathological alterations that appeared in ALCL₃-treated rats’ hippocampi. The above micrographical photos (H&E×400) display rats’ hippocampal sections collected on day 61 of this work. a Control group: revealed normal organization and structure of neuronal cells with normal appearance of the hippocampus. b ALCL₃ group: revealed abnormal appearance of the neurons and their nuclei, necrosis and neurodegenerative changes. c Cilostazol group: showed normal appearance of the hippocampus. d AlCl3 + cilostazol group: showed alleviation of the neurodegenerative pathological changes that were observed in ALCL₃-treated rats’ hippocampi