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. 2022 Sep 8;48(1):211–212. doi: 10.1038/s41386-022-01446-7

Fig. 1. Potential mechanisms of action of the fungal bioactive psilocybin in AUD.

Fig. 1

Psilocybin’s cellular and systemic effects may range from unlocking a transcriptional blockade via epigenetic reprogramming, direct interactions on the receptor level e.g., through stable 5HT2A/mGluR2 heterodimerization, interference with altered brain networks to reactivate glutamatergic signaling in the mPFC or may impact on the alcohol or withdrawal induced microglia response (Figure modified from Meinhardt & Sommer 2015 [10.1111/adb.12187] and created with www.biorender.com).