Dear Colleagues,
Welcome to another issue of AACE Clinical Case Reports (ACCR)! The current issue includes many interesting and educational case reports to share. We will provide a summary of some of those cases below. For more details, please access ACCR online journal available at https://www.aaceclinicalcasereports.com/
Under the many cases on Pituitary-Gonadal-Adrenal Access in this issue, we selected the following: In an interesting case, authors described the diagnostic challenges related to excess cortisol due to exogenous use of glucocorticoids containing “herbal” supplements.1 Another case described the outcome of hypopituitarism in a patient with acquired immunodeficiency syndrome and pituitary abscess.2 A different case also highlighted the risk of thrombotic events associated with Cushing syndrome and the need for clear recommendations on the duration of postoperative thromboprophylaxis in those patients.3 Authors also described the effect of retinoic acid in treating cutaneous T-cell lymphona, not only on causing central hypothyroidism but also central adrenal insufficiency.4 The issue included a case of recurrent Cushing syndrome with metastatic adrenocortical carcinoma in a patient with previously resected adrenal adenoma and found to have fumarate hydratase alelic variant suggesting potential contribution to disease progression.5
Another case highlighted the potential risk for rhabdomyolysis associated with IM testosterone enanthate injection for gender-affirming hormonal therapy.6 Another case included in this issue described the off-label use of osilodrostat, currently FDA-approved for Cushing disease treatment, to reduce cortisol level and disease severity prior to planned adrenalectomy in Cushing syndrome due to adrenal origin.7 In addition, a case with nonclassic congenital adrenal hyperplasia (NCCAH) presented in a patient with CYP21A2 and CYP11B1 heterozygous mutations, suggesting dual heterozygous mutations and adding to the database of described mutations in NCCAH.8 Lastly, under image vignettes, a case of growth hormone producing pituitary adenoma was described.9
On Bone and Minerals, authors report an interesting case suggesting a potential correlation between spondylodysplastic Ehlers-Danlos syndrome (spEDS), a rare heritable connective tissue disorder, with hypophosphatasia, a heritable disorder caused by a genetic sequence variation in the ALPL gene and affecting bone mineralization.10
In the field of Thyroid Disease, authors shared an interesting video describing radiofrequency ablation of recurrent metastatic papillary thyroid cancer in a lymph node.11 A visual vignette of rapidly enlarging neck mass as a common presentation of anaplastic thyroid cancer was also described.12
We would like to invite all authors to share their interesting cases on Diabetes & Metabolism, incorporating the newly released diabetes guidelines to be considered for publication in our journal special issue. For detailed description of each category, please refer to “Guide for Authors” link: https://www.elsevier.com/journals/aace-clinical-case-reports/2376-0605/guide-for-authors
As always, I truly appreciate all contributing authors, reviewers, editors, and staff that help improve our journal and create an educational platform to our readers to help best manage our patients.
Thank you again for your interest in ACCR. I welcome all feedback, questions, and comments from our readers. Please feel free to reach us at publications@aace.com.
Warmest regards,
References
- 1.Patel R., Sherf S., Lai N.B., et al. Exogenous Cushing syndrome caused by a “herbal” supplement. AACE Clin Case Rep. 2022;8(6):239–242. doi: 10.1016/j.aace.2022.08.001. [DOI] [PMC free article] [PubMed] [Google Scholar]
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