Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries

Aniket Mishra; Rainer Malik; Tsuyoshi Hachiya; Tuuli Jürgenson; Shinichi Namba; Daniel C Posner; Frederick K Kamanu; Masaru Koido; Quentin Le Grand; Mingyang Shi; Yunye He; Marios K Georgakis; Ilana Caro; Kristi Krebs; Yi-Ching Liaw; Felix C Vaura; Kuang Lin; Bendik Slagsvold Winsvold; Vinodh Srinivasasainagendra; Livia Parodi; Hee-Joon Bae; Ganesh Chauhan; Michael R Chong; Liisa Tomppo; Rufus Akinyemi; Gennady V Roshchupkin; Naomi Habib; Yon Ho Jee; Jesper Qvist Thomassen; Vida Abedi; Jara Cárcel-Márquez; Marianne Nygaard; Hampton L Leonard; Chaojie Yang; Ekaterina Yonova-Doing; Maria J Knol; Adam J Lewis; Renae L Judy; Tetsuro Ago; Philippe Amouyel; Nicole D Armstrong; Mark K Bakker; Traci M Bartz; David A Bennett; Joshua C Bis; Constance Bordes; Sigrid Børte; Anael Cain; Paul M Ridker; Kelly Cho; Zhengming Chen; Carlos Cruchaga; John W Cole; Phil L de Jager; Rafael de Cid; Matthias Endres; Leslie E Ferreira; Mirjam I Geerlings; Natalie C Gasca; Vilmundur Gudnason; Jun Hata; Jing He; Alicia K Heath; Yuk-Lam Ho; Aki S Havulinna; Jemma C Hopewell; Hyacinth I Hyacinth; Michael Inouye; Mina A Jacob; Christina E Jeon; Christina Jern; Masahiro Kamouchi; Keith L Keene; Takanari Kitazono; Steven J Kittner; Takahiro Konuma; Amit Kumar; Paul Lacaze; Lenore J Launer; Keon-Joo Lee; Kaido Lepik; Jiang Li; Liming Li; Ani Manichaikul; Hugh S Markus; Nicholas A Marston; Thomas Meitinger; Braxton D Mitchell; Felipe A Montellano; Takayuki Morisaki; Thomas H Mosley; Mike A Nalls; Børge G Nordestgaard; Martin J O’Donnell; Yukinori Okada; N Charlotte Onland-Moret; Bruce Ovbiagele; Annette Peters; Bruce M Psaty; Stephen S Rich

doi:10.1038/s41586-022-05492-5

. 2022 Nov 14;612(7938):E7. doi: 10.1038/s41586-022-05492-5

Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries

Aniket Mishra ^1,^#, Rainer Malik ^2,^#, Tsuyoshi Hachiya ^3,^#, Tuuli Jürgenson ^4,^5,^#, Shinichi Namba ^6,^#, Daniel C Posner ^7,^#, Frederick K Kamanu ^8,⁹, Masaru Koido ^10,¹¹, Quentin Le Grand ¹, Mingyang Shi ¹¹, Yunye He ¹¹, Marios K Georgakis ^2,^12,¹³, Ilana Caro ¹, Kristi Krebs ⁴, Yi-Ching Liaw ^14,¹⁵, Felix C Vaura ^16,¹⁷, Kuang Lin ¹⁸, Bendik Slagsvold Winsvold ^19,^20,²¹, Vinodh Srinivasasainagendra ²², Livia Parodi ^12,¹³, Hee-Joon Bae ²³, Ganesh Chauhan ²⁴, Michael R Chong ^25,²⁶, Liisa Tomppo ²⁷, Rufus Akinyemi ^28,²⁹, Gennady V Roshchupkin ^30,³¹, Naomi Habib ³², Yon Ho Jee ³³, Jesper Qvist Thomassen ³⁴, Vida Abedi ^35,³⁶, Jara Cárcel-Márquez ^37,³⁸, Marianne Nygaard ^39,⁴⁰, Hampton L Leonard ^41,^42,⁴³, Chaojie Yang ^44,⁴⁵, Ekaterina Yonova-Doing ^46,⁴⁷, Maria J Knol ³⁰, Adam J Lewis ⁴⁸, Renae L Judy ⁴⁹, Tetsuro Ago ⁵⁰, Philippe Amouyel ^51,^52,⁵³, Nicole D Armstrong ⁵⁴, Mark K Bakker ⁵⁵, Traci M Bartz ^56,⁵⁷, David A Bennett ⁵⁸, Joshua C Bis ⁵⁶, Constance Bordes ¹, Sigrid Børte ^20,^59,⁶⁰, Anael Cain ³², Paul M Ridker ^61,⁶², Kelly Cho ⁷, Zhengming Chen ^18,⁶³, Carlos Cruchaga ^64,⁶⁵, John W Cole ^66,⁶⁷, Phil L de Jager ^13,⁶⁸, Rafael de Cid ⁶⁹, Matthias Endres ^70,^71,^72,⁷³, Leslie E Ferreira ⁷⁴, Mirjam I Geerlings ⁷⁵, Natalie C Gasca ⁵⁷, Vilmundur Gudnason ^76,⁷⁷, Jun Hata ⁷⁸, Jing He ⁴⁸, Alicia K Heath ⁷⁹, Yuk-Lam Ho ⁷, Aki S Havulinna ^80,⁸¹, Jemma C Hopewell ⁸², Hyacinth I Hyacinth ⁸³, Michael Inouye ^46,^84,^85,^86,⁸⁷, Mina A Jacob ⁸⁸, Christina E Jeon ⁸⁹, Christina Jern ^90,⁹¹, Masahiro Kamouchi ⁹², Keith L Keene ⁹³, Takanari Kitazono ⁵⁰, Steven J Kittner ^67,⁹⁴, Takahiro Konuma ⁶, Amit Kumar ²⁴, Paul Lacaze ⁹⁵, Lenore J Launer ⁹⁶, Keon-Joo Lee ⁹⁷, Kaido Lepik ^4,^98,^99,¹⁰⁰, Jiang Li ³⁵, Liming Li ¹⁰¹, Ani Manichaikul ⁴⁴, Hugh S Markus ¹⁰², Nicholas A Marston ^8,⁹, Thomas Meitinger ^103,¹⁰⁴, Braxton D Mitchell ^105,¹⁰⁶, Felipe A Montellano ^107,¹⁰⁸, Takayuki Morisaki ¹⁰, Thomas H Mosley ¹⁰⁹, Mike A Nalls ^41,^42,⁴³, Børge G Nordestgaard ^110,¹¹¹, Martin J O’Donnell ¹¹², Yukinori Okada ^6,^113,^114,^115,^116,¹¹⁷, N Charlotte Onland-Moret ⁷⁵, Bruce Ovbiagele ¹¹⁸, Annette Peters ^119,^120,¹²¹, Bruce M Psaty ^56,^122,¹²³, Stephen S Rich ⁴⁴, Jonathan Rosand ^12,^13,¹²⁴, Marc S Sabatine ^8,⁹, Ralph L Sacco ^125,¹²⁶, Danish Saleheen ¹²⁷, Else Charlotte Sandset ^128,¹²⁹, Veikko Salomaa ⁸⁰, Muralidharan Sargurupremraj ¹³⁰, Makoto Sasaki ³, Claudia L Satizabal ^130,¹³¹, Carsten O Schmidt ¹³², Atsushi Shimizu ³, Nicholas L Smith ^122,^133,¹³⁴, Kelly L Sloane ¹³⁵, Yoichi Sutoh ³, Yan V Sun ^136,¹³⁷, Kozo Tanno ³, Steffen Tiedt ², Turgut Tatlisumak ¹³⁸, Nuria P Torres-Aguila ³⁷, Hemant K Tiwari ²², David-Alexandre Trégouët ¹, Stella Trompet ^139,¹⁴⁰, Anil Man Tuladhar ⁸⁸, Anne Tybjærg-Hansen ^34,¹¹¹, Marion van Vugt ¹⁴¹, Riina Vibo ¹⁴², Shefali S Verma ¹⁴³, Kerri L Wiggins ⁵⁶, Patrik Wennberg ¹⁴⁴, Daniel Woo ⁸³, Peter W F Wilson ^136,¹⁴⁵, Huichun Xu ¹⁰⁵, Qiong Yang ^131,¹⁴⁶, Kyungheon Yoon ¹⁴⁷; The COMPASS Consortium^379,^380,^381,^382,^383,^384,^385,^386,^387,^388,^389,^390,^391,^392,^393,^394,^395,^396,^397,^398,^399,^400,^401,^402,^403,^404,^405,^406,^407,^408,^409,^410,^411,^412,^413,^414,^415,^416,⁴¹⁷; The INVENT Consortium^379,^380,^381,^382,^383,^384,^385,^386,^387,^388,^389,^390,^391,^392,^393,^394,^395,^396,^397,^398,^399,^400,^401,^402,^403,^404,^405,^406,^407,^408,^409,^410,^411,^412,^413,^414,^415,^416,⁴¹⁷; The Dutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study Group^379,^380,^381,^382,^383,^384,^385,^386,^387,^388,^389,^390,^391,^392,^393,^394,^395,^396,^397,^398,^399,^400,^401,^402,^403,^404,^405,^406,^407,^408,^409,^410,^411,^412,^413,^414,^415,^416,⁴¹⁷; The Estonian Biobank^379,^380,^381,^382,^383,^384,^385,^386,^387,^388,^389,^390,^391,^392,^393,^394,^395,^396,^397,^398,^399,^400,^401,^402,^403,^404,^405,^406,^407,^408,^409,^410,^411,^412,^413,^414,^415,^416,⁴¹⁷; The PRECISE4Q Consortium^379,^380,^381,^382,^383,^384,^385,^386,^387,^388,^389,^390,^391,^392,^393,^394,^395,^396,^397,^398,^399,^400,^401,^402,^403,^404,^405,^406,^407,^408,^409,^410,^411,^412,^413,^414,^415,^416,⁴¹⁷; The FinnGen Consortium^379,^380,^381,^382,^383,^384,^385,^386,^387,^388,^389,^390,^391,^392,^393,^394,^395,^396,^397,^398,^399,^400,^401,^402,^403,^404,^405,^406,^407,^408,^409,^410,^411,^412,^413,^414,^415,^416,⁴¹⁷; The NINDS Stroke Genetics Network (SiGN)^379,^380,^381,^382,^383,^384,^385,^386,^387,^388,^389,^390,^391,^392,^393,^394,^395,^396,^397,^398,^399,^400,^401,^402,^403,^404,^405,^406,^407,^408,^409,^410,^411,^412,^413,^414,^415,^416,⁴¹⁷; The MEGASTROKE Consortium^379,^380,^381,^382,^383,^384,^385,^386,^387,^388,^389,^390,^391,^392,^393,^394,^395,^396,^397,^398,^399,^400,^401,^402,^403,^404,^405,^406,^407,^408,^409,^410,^411,^412,^413,^414,^415,^416,⁴¹⁷; The SIREN Consortium^379,^380,^381,^382,^383,^384,^385,^386,^387,^388,^389,^390,^391,^392,^393,^394,^395,^396,^397,^398,^399,^400,^401,^402,^403,^404,^405,^406,^407,^408,^409,^410,^411,^412,^413,^414,^415,^416,⁴¹⁷; The China Kadoorie Biobank Collaborative Group^379,^380,^381,^382,^383,^384,^385,^386,^387,^388,^389,^390,^391,^392,^393,^394,^395,^396,^397,^398,^399,^400,^401,^402,^403,^404,^405,^406,^407,^408,^409,^410,^411,^412,^413,^414,^415,^416,⁴¹⁷; The VA Million Veteran Program^379,^380,^381,^382,^383,^384,^385,^386,^387,^388,^389,^390,^391,^392,^393,^394,^395,^396,^397,^398,^399,^400,^401,^402,^403,^404,^405,^406,^407,^408,^409,^410,^411,^412,^413,^414,^415,^416,⁴¹⁷; The International Stroke Genetics Consortium (ISGC)^379,^380,^381,^382,^383,^384,^385,^386,^387,^388,^389,^390,^391,^392,^393,^394,^395,^396,^397,^398,^399,^400,^401,^402,^403,^404,^405,^406,^407,^408,^409,^410,^411,^412,^413,^414,^415,^416,⁴¹⁷; The Biobank Japan^379,^380,^381,^382,^383,^384,^385,^386,^387,^388,^389,^390,^391,^392,^393,^394,^395,^396,^397,^398,^399,^400,^401,^402,^403,^404,^405,^406,^407,^408,^409,^410,^411,^412,^413,^414,^415,^416,⁴¹⁷; The CHARGE Consortium^379,^380,^381,^382,^383,^384,^385,^386,^387,^388,^389,^390,^391,^392,^393,^394,^395,^396,^397,^398,^399,^400,^401,^402,^403,^404,^405,^406,^407,^408,^409,^410,^411,^412,^413,^414,^415,^416,⁴¹⁷; The GIGASTROKE Consortium^379,^380,^381,^382,^383,^384,^385,^386,^387,^388,^389,^390,^391,^392,^393,^394,^395,^396,^397,^398,^399,^400,^401,^402,^403,^404,^405,^406,^407,^408,^409,^410,^411,^412,^413,^414,^415,^416,⁴¹⁷, Iona Y Millwood ^18,⁶³, Christian Gieger ¹⁴⁸, Toshiharu Ninomiya ⁷⁸, Hans J Grabe ^149,¹⁵⁰, J Wouter Jukema ^140,^151,¹⁵², Ina L Rissanen ⁷⁵, Daniel Strbian ²⁷, Young Jin Kim ¹⁴⁷, Pei-Hsin Chen ¹⁵, Ernst Mayerhofer ^12,¹³, Joanna M M Howson ^46,⁴⁷, Marguerite R Irvin ⁵⁴, Hieab Adams ^153,¹⁵⁴, Sylvia Wassertheil-Smoller ¹⁵⁵, Kaare Christensen ^39,^40,¹⁵⁶, Mohammad A Ikram ³⁰, Tatjana Rundek ^125,¹²⁶, Bradford B Worrall ^157,¹⁵⁸, G Mark Lathrop ¹⁵⁹, Moeen Riaz ⁹⁵, Eleanor M Simonsick ¹⁶⁰, Janika Kõrv ¹⁴², Paulo H C França ⁷⁴, Ramin Zand ^161,¹⁶², Kameshwar Prasad ²⁴, Ruth Frikke-Schmidt ^34,¹¹¹, Frank-Erik de Leeuw ⁸⁸, Thomas Liman ^71,^75,¹⁶³, Karl Georg Haeusler ¹⁰⁸, Ynte M Ruigrok ⁵⁵, Peter Ulrich Heuschmann ^107,^164,¹⁶⁵, W T Longstreth ^122,¹⁶⁶, Keum Ji Jung ^18,¹⁶⁷, Lisa Bastarache ⁴⁸, Guillaume Paré ^25,^26,^168,¹⁶⁹, Scott M Damrauer ^170,¹⁷¹, Daniel I Chasman ^61,⁶², Jerome I Rotter ¹⁷², Christopher D Anderson ^12,^13,^124,¹⁷³, John-Anker Zwart ^19,^20,⁵⁹, Teemu J Niiranen ^16,^17,¹⁷⁴, Myriam Fornage ^175,¹⁷⁶, Yung-Po Liaw ^15,¹⁷⁷, Sudha Seshadri ^130,^131,¹⁷⁸, Israel Fernández-Cadenas ³⁷, Robin G Walters ^18,⁶³, Christian T Ruff ^8,⁹, Mayowa O Owolabi ^28,¹⁷⁹, Jennifer E Huffman ⁷, Lili Milani ⁴, Yoichiro Kamatani ¹¹, Martin Dichgans ^2,^180,^181,^✉, Stephanie Debette ^1,^182,^✉

¹Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France

²Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany

³Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan

⁴Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia

⁵Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia

⁶Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan

⁷Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA USA

⁸TIMI Study Group, Boston, MA USA

⁹Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA USA

¹⁰Division of Molecular Pathology, Institute of Medical Sciences, The University of Tokyo, Tokyo, Japan

¹¹Laboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan

¹²Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA USA

¹³Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA USA

¹⁴Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan

¹⁵Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, Taiwan

¹⁶Department of Internal Medicine, University of Turku, Turku, Finland

¹⁷Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Turku, Finland

¹⁸Nuffield Department of Population Health, University of Oxford, Oxford, UK

¹⁹Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway

²⁰K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

²¹Department of Neurology, Oslo University Hospital, Oslo, Norway

²²Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL USA

²³Department of Neurology and Cerebrovascular Disease Center, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea

²⁴Rajendra Institute of Medical Sciences, Ranchi, India

²⁵Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario Canada

²⁶Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario Canada

²⁷Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland

²⁸Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria

²⁹Neuroscience and Ageing Research Unit Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria

³⁰Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands

³¹Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands

³²The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

³³Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA USA

³⁴Department of Clinical Biochemistry, Copenhagen University Hospital—Rigshospitalet, Copenhagen, Denmark

³⁵Department of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, VA USA

³⁶Department of Public Health Sciences, College of Medicine, The Pennsylvania State University, State College, PA USA

³⁷Stroke Pharmacogenomics and Genetics Laboratory, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain

³⁸Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain

³⁹The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark

⁴⁰Department of Clinical Genetics, Odense University Hospital, Odense, Denmark

⁴¹Center for Alzheimer’s and Related Dementias, National Institutes of Health, Bethesda, MD USA

⁴²Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD USA

⁴³Data Tecnica International, Glen Echo, MD USA

⁴⁴Center for Public Health Genomics, University of Virginia, Charlottesville, VA USA

⁴⁵Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA USA

⁴⁶British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

⁴⁷Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK

⁴⁸Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN USA

⁴⁹Department of Surgery, University of Pennsylvania, Philadelphia, PA USA

⁵⁰Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

⁵¹University of Lille, INSERM U1167, RID-AGE, LabEx DISTALZ, Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France

⁵²CHU Lille, Public Health Department, Lille, France

⁵³Institut Pasteur de Lille, Lille, France

⁵⁴Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL USA

⁵⁵UMC Utrecht Brain Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands

⁵⁶Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA USA

⁵⁷Department of Biostatistics, University of Washington, Seattle, WA USA

⁵⁸Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL USA

⁵⁹Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

⁶⁰Research and Communication Unit for Musculoskeletal Health (FORMI), Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway

⁶¹Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA USA

⁶²Harvard Medical School, Boston, MA USA

⁶³MRC Population Health Research Unit, University of Oxford, Oxford, UK

⁶⁴Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO USA

⁶⁵NeuroGenomics and Informatics Center, Washington University School of Medicine, Saint Louis, MO USA

⁶⁶VA Maryland Health Care System, Baltimore, MD USA

⁶⁷Department of Neurology, University of Maryland School of Medicine, Baltimore, MD USA

⁶⁸Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY USA

⁶⁹GenomesForLife—GCAT Lab Group, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain

⁷⁰Klinik und Hochschulambulanz für Neurologie, Charité—Universitätsmedizin Berlin, Berlin, Germany

⁷¹Center for Stroke Research Berlin, Berlin, Germany

⁷²German Center for Neurodegenerative Diseases (DZNE), partner site Berlin, Berlin, Germany

⁷³German Centre for Cardiovascular Research (DZHK), partner site Berlin, Berlin, Germany

⁷⁴Post-Graduation Program on Health and Environment, Department of Medicine and Joinville Stroke Biobank, University of the Region of Joinville, Santa Catarina, Brazil

⁷⁵Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

⁷⁶Icelandic Heart Association, Kopavogur, Iceland

⁷⁷Faculty of Medicine, University of Iceland, Reykjavik, Iceland

⁷⁸Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

⁷⁹Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK

⁸⁰Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland

⁸¹Institute for Molecular Medicine Finland, FIMM-HiLIFE, Helsinki, Finland

⁸²Clinical Trial Service and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK

⁸³Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH USA

⁸⁴Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

⁸⁵Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Victoria Australia

⁸⁶Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK

⁸⁷British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK

⁸⁸Department of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands

⁸⁹Los Angeles County Department of Public Health, Los Angeles, CA USA

⁹⁰Institute of Biomedicine, Department of Laboratory Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

⁹¹Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden

⁹²Department of Health Care Administration and Management, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

⁹³Department of Biology, Brody School of Medicine Center for Health Disparities, East Carolina University, Greenville, NC USA

⁹⁴Department of Neurology and Geriatric Research and Education Clinical Center, VA Maryland Health Care System, Baltimore, MD USA

⁹⁵Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria Australia

⁹⁶Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD USA

⁹⁷Department of Neurology, Korea University Guro Hospital, Seoul, Republic of Korea

⁹⁸Department of Computational Biology, University of Lausanne, Lausanne, Switzerland

⁹⁹Swiss Institute of Bioinformatics, Lausanne, Switzerland

¹⁰⁰University Center for Primary Care and Public Health, Lausanne, Switzerland

¹⁰¹Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China

¹⁰²Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK

¹⁰³Institute of Human Genetics, Technical University of Munich, Munich, Germany

¹⁰⁴Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

¹⁰⁵Department of Medicine, University of Maryland School of Medicine, Baltimore, MD USA

¹⁰⁶Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD USA

¹⁰⁷Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany

¹⁰⁸Department of Neurology, University Hospital Würzburg, Würzburg, Germany

¹⁰⁹The MIND Center, University of Mississippi Medical Center, Jackson, MS USA

¹¹⁰Department of Clinical Biochemistry, Copenhagen University Hospital—Herlev and Gentofte, Copenhagen, Denmark

¹¹¹Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

¹¹²College of Medicine Nursing and Health Science, NUI Galway, Galway, Ireland

¹¹³Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

¹¹⁴Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

¹¹⁵Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan

¹¹⁶Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan

¹¹⁷Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan

¹¹⁸Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA USA

¹¹⁹Institute of Epidemiology, Helmholtz Zentrum München,, German Research Center for Environmental Health, Neuherberg, Germany

¹²⁰Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilian University Munich, Munich, Germany

¹²¹German Centre for Cardiovascular Research (DZHK), partner site Munich, Munich, Germany

¹²²Department of Epidemiology, University of Washington, Seattle, WA USA

¹²³Department of Health Systems and Population Health, University of Washington, Seattle, WA USA

¹²⁴McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA USA

¹²⁵Department of Neurology, University of Miami Miller School of Medicine, Miami, FL USA

¹²⁶Evelyn F. McKnight Brain Institute, Gainesville, FL USA

¹²⁷Division of Cardiology, Department of Medicine, Columbia University, New York, NY USA

¹²⁸Stroke Unit, Department of Neurology, Oslo University Hospital, Oslo, Norway

¹²⁹Research and Development, The Norwegian Air Ambulance Foundation, Oslo, Norway

¹³⁰Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX USA

¹³¹Framingham Heart Study, Framingham, MA USA

¹³²University Medicine Greifswald, Institute for Community Medicine, SHIP/KEF, Greifswald, Germany

¹³³Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA USA

¹³⁴Department of Veterans Affairs Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, WA USA

¹³⁵Department of Neurology, University of Pennsylvania, Philadelphia, PA USA

¹³⁶Atlanta VA Health Care System, Decatur, GA USA

¹³⁷Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA USA

¹³⁸Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Unviersity Hospital, Gothenburg, Sweden

¹³⁹Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands

¹⁴⁰Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

¹⁴¹Division Heart & Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

¹⁴²Department of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia

¹⁴³Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA USA

¹⁴⁴Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

¹⁴⁵Department of Medicine, Division of Cardiovascular Disease, Emory University School of Medicine, Atlanta, GA USA

¹⁴⁶Department of Biostatistics, Boston University School of Public Health, Boston, MA USA

¹⁴⁷Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, Republic of Korea

¹⁴⁸Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

¹⁴⁹Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany

¹⁵⁰German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald, Rostock, Germany

¹⁵¹Netherlands Heart Institute, Utrecht, The Netherlands

¹⁵²Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, The Netherlands

¹⁵³Department of Clinical Genetics, Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands

¹⁵⁴Latin American Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile

¹⁵⁵Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY USA

¹⁵⁶Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark

¹⁵⁷Department of Neurology, University of Virginia, Charlottesville, VA USA

¹⁵⁸Department of Public Health Science, University of Virginia, Charlottesville, VA USA

¹⁵⁹McGill Genome Centre, Montreal, Quebec Canada

¹⁶⁰Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD USA

¹⁶¹Geisinger Neuroscience Institute, Geisinger Health System, Danville, PA USA

¹⁶²Department of Neurology, College of Medicine, The Pennsylvania State University, State College, PA USA

¹⁶³Klinik für Neurologie, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany

¹⁶⁴Comprehensive Heart Failure Center, University Hospital Würzburg, Würzburg, Germany

¹⁶⁵Clinical Trial Center, University Hospital Würzburg, Würzburg, Germany

¹⁶⁶Department of Neurology, University of Washington, Seattle, WA USA

¹⁶⁷Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea

¹⁶⁸Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario Canada

¹⁶⁹Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Hamilton, Ontario Canada

¹⁷⁰Department of Surgery and Department of Genetics, University of Pennsylvania, Philadelphia, PA USA

¹⁷¹Corporal Michael Crescenz VA Medical Center, Philadelphia, PA USA

¹⁷²The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA

¹⁷³Department of Neurology, Brigham and Women’s Hospital, Boston, MA USA

¹⁷⁴Division of Medicine, Turku University Hospital, Turku, Finland

¹⁷⁵Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX USA

¹⁷⁶Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX USA

¹⁷⁷Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

¹⁷⁸Department of Neurology, Boston University School of Medicine, Boston, MA USA

¹⁷⁹Department of Medicine, University of Ibadan, Ibadan, Nigeria

¹⁸⁰Munich Cluster for Systems Neurology, Munich, Germany

¹⁸¹German Center for Neurodegenerative Diseases (DZNE), Munich, Germany

¹⁸²Department of Neurology, Institute for Neurodegenerative Diseases, CHU de Bordeaux, Bordeaux, France

¹⁸³Department of Neurology, Washington University School of Medicine, Saint Louis, MO USA

¹⁸⁴Baltimore Veterans Administration Medical Center and University of Maryland School of Medicine, Baltimore, MD USA

¹⁸⁵Mayo Clinic Florida, Jacksonville, FL USA

¹⁸⁶Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Baltimore, MD USA

¹⁸⁷University of Mississippi Medical Center, Jackson, MS USA

¹⁸⁸William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

¹⁸⁹Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, UK

¹⁹⁰Initiative for Research and Education to Advance Community Health, Washington State University, Seattle, WA USA

¹⁹¹Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA USA

¹⁹²Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC USA

¹⁹³Johns Hopkins University School of Medicine, Baltimore, MD USA

¹⁹⁴Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD USA

¹⁹⁵Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD USA

¹⁹⁶University of California, San Francisco, San Francisco, CA USA

¹⁹⁷University of Colorado Anschutz Medical Campus, Denver, CO USA

¹⁹⁸Brown University Warren Alpert Medical School, Providence, RI USA

¹⁹⁹College of Public Health, University of Kentucky, Lexington, KY USA

²⁰⁰University of British Columbia, Vancouver, British Columbia Canada

²⁰¹Neuroscience Institute, Saint Francis Medical Center, Trenton, NJ USA

²⁰²HUNT Research Center, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

²⁰³Department of Research, Innovation and Education, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

²⁰⁴Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA USA

²⁰⁵Department of Pediatrics and Rady Children’s Hospital, University of California San Diego, La Jolla, CA USA

²⁰⁶K. G. Jebsen Thrombosis Research and Expertise Center, Department of Clinical Medicine, UiT—The Arctic University of Norway, Tromsø, Norway

²⁰⁷Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

²⁰⁸Department of Health Sciences Research, Mayo Clinic, Rochester, MN USA

²⁰⁹Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN USA

²¹⁰MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK

²¹¹Clinic of Thoracic and Occupational Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

²¹²Laboratory of Haematology, La Timone Hospital, Marseille, France

²¹³C2VN, University of Aix Marseille, INSERM, INRAE, C2VN, Marseille, France

²¹⁴Institute of Genomic Medicine, University of California, San Diego, La Jolla, CA USA

²¹⁵Program in Genetic Epidemiology and Statistical Genetics, Harvard T. H. Chan School of Public Health, Boston, MA USA

²¹⁶Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway

²¹⁷Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN USA

²¹⁸Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH USA

²¹⁹Department of Internal Medicine and the Center for Clinical and Translational Science, Ohio State University, Columbus, OH USA

²²⁰Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI USA

²²¹Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark

²²²Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor–UCLA Medical Center, Torrance, CA USA

²²³Division of Genomic Outcomes, Department of Pediatrics, Harbor–UCLA Medical Center, Torrance, CA USA

²²⁴Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN USA

²²⁵Centre National de Recherche en Génomique Humaine, Direction de la Recherche Fondamentale, CEA, Evry, France

²²⁶CEPH-Fondation Jean Dausset, Paris, France

²²⁷Million Veteran’s Program, Veteran’s Administration, Boston, MA USA

²²⁸CRB Assistance Publique—Hôpitaux de Marseille, HemoVasc (CRB AP-HM HemoVasc), Marseille, France

²²⁹Center for Vascular Emergencies, Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA USA

²³⁰Department of Emergency Medicine, Harvard Medical School, Boston, MA USA

²³¹Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands

²³²Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands

²³³Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

²³⁴Department of Neurology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands

²³⁵Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands

²³⁶John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, New South Wales Australia

²³⁷Faculty of Health, University of Technology Sydney, Ultimo, New South Wales Australia

²³⁸Department of Neurology, IMIM-Hospital del Mar, Neurovascular Research Group, IMIM (Institut Hospital del Mar d’Investigacions Mèdiques), Universitat Autònoma de Barcelona/DCEXS-Universitat Pompeu Fabra, Barcelona, Spain

²³⁹Institute of Cardiovascular Research, Royal Holloway University of London, London, UK

²⁴⁰Ashford and St Peters Hospital, Chertsey, UK

²⁴¹Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK

²⁴²Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK

²⁴³Department of Neurology, Medical University of Graz, Graz, Austria

²⁴⁴Department of Neurology, Jagiellonian University, Krakow, Poland

²⁴⁵Stroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Melbourne, Victoria Australia

²⁴⁶Department of Neurology, Austin Health, Heidelberg, Victoria Australia

²⁴⁷Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden

²⁴⁸Department of Neurology, Rehabilitation Medicine, Memory Disorders, Geriatrics, Skåne University Hospital, Lund, Sweden

²⁴⁹Department of Clinical Sciences, Lund University, Malmö, Sweden

²⁵⁰Department of Medicine, Brigham and Women’s Hospital, Boston, MA USA

²⁵¹Wolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK

²⁵²Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, FL USA

²⁵³Division of Cardiovascular Medicine, College of Medicine, University of Florida, Gainesville, FL USA

²⁵⁴BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

²⁵⁵NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

²⁵⁶Wellcome Trust Sanger Institute, Cambridge, UK

²⁵⁷British Heart Foundation Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge, UK

²⁵⁸National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK

²⁵⁹Department of Emergency Medicine, Washington University School of Medicine, Saint Louis, MO USA

²⁶⁰Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico ‘Carlo Besta’, Milan, Italy

²⁶¹Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

²⁶²Department of Clinical and Experimental Sciences, Neurology Clinic, University of Brescia, Brescia, Italy

²⁶³Albrecht Kossel Institute, University Clinic of Rostock, Rostock, Germany

²⁶⁴Department of Neurology, Massachusetts General Hospital (MGH), Harvard Medical School, Boston, MA USA

²⁶⁵Survey Research Center, University of Michigan, Ann Arbor, MI USA

²⁶⁶Department of Neurosciences, Experimental Neurology, KU Leuven–University of Leuven, Leuven, Belgium

²⁶⁷Department of Neurology, VIB Center for Brain & Disease Research, University Hospitals Leuven, Leuven, Belgium

²⁶⁸Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT USA

²⁶⁹Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

²⁷⁰Region Västra Götaland, Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden

²⁷¹Chang Gung Memorial Hospital, Linkou Medical Center in Taiwan, Taoyuan City, Taiwan

²⁷²Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA USA

²⁷³Department of Neurology, University Medicine Greifswald, Greifswald, Germany

²⁷⁴Stroke Pharmacogenomics and Genetics Laboratory, Fundación Docència I Recerca Mútua Terrassa, Hospital Mútua Terrassa, Terrassa, Spain

²⁷⁵Neurovascular Research Laboratory, Vall d’Hebron Institute of Research, Universitat Autònoma de Barcelona, Barcelona, Spain

²⁷⁶Neurology Service, Hospital Universitari Mútua Terrassa, Terrassa, Spain

²⁷⁷Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA USA

²⁷⁸Institute de Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC/University of Seville and Department of Neurology, Hospital Universitario Virgen Macarena, Seville, Spain

²⁷⁹Department of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), UTHealth Science Center, School of Public Health, Houston, TX USA

²⁸⁰BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, University of Glasgow, Glasgow, UK

²⁸¹German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany

²⁸²Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA USA

²⁸³Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan

²⁸⁴deCODE genetics/AMGEN, Reykjavik, Iceland

²⁸⁵J. Philip Kistler Stroke Research Center, Department of Neurology, MGH, Boston, MA USA

²⁸⁶Population Health Research Institute, McMaster University, Hamilton, Ontario Canada

²⁸⁷AA Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, Boston, MA USA

²⁸⁸School of Life Science, University of Lincoln, Lincoln, UK

²⁸⁹Department of Neurology, Mayo Clinic, Rochester, MN USA

²⁹⁰Stroke Pharmacogenomics and Genetics, Fundacio Docència i Recerca MutuaTerrassa, Terrassa, Spain

²⁹¹Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

²⁹²Boston University School of Public Health, Boston, MA USA

²⁹³The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and Science for Life Laboratory, Uppsala, Sweden

²⁹⁴Department of Genetics, University of North Carolina, Chapel Hill, NC USA

²⁹⁵Department of Neurology and Stroke Center, Basel University Hospital, Basel, Switzerland

²⁹⁶Neurorehabilitation Unit, University of Basel and University Center for Medicine of Aging and Rehabilitation Basel, Felix Platter Hospital, Basel, Switzerland

²⁹⁷Department of Neurology, Yale University School of Medicine, New Haven, CT USA

²⁹⁸Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

²⁹⁹Department of Neurology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK

³⁰⁰Public Health Stream, Hunter Medical Research Institute, New Lambton, New South Wales Australia

³⁰¹College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, New South Wales Australia

³⁰²Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC USA

³⁰³Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA USA

³⁰⁴MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, UK

³⁰⁵ Computational Medicine, Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Berlin, Germany

³⁰⁶ Precision Healthcare Institute, Queen Mary University of London, London, UK

³⁰⁷INSERM U 1172, CHU Lille, Université Lille, Lille, France

³⁰⁸MRC Biostatistics Unit, University of Cambridge, Cambridge, UK

³⁰⁹Bioinformatics Core Facility, University of Gothenburg, Gothenburg, Sweden

³¹⁰Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

³¹¹Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

³¹²Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK USA

³¹³Department of Neurology, Justus Liebig University, Giessen, Germany

³¹⁴Department of Public Health, Bordeaux University Hospital, Bordeaux, France

³¹⁵School of Medicine, Dentistry and Nursing at the University of Glasgow, Glasgow, UK

³¹⁶University of Newcastle and Hunter Medical Research Institute, New Lambton, New South Wales Australia

³¹⁷INM, University of Montpellier Inserm U1298, Montpellier, France

³¹⁸Centre for Research in Environmental Epidemiology, Barcelona, Spain

³¹⁹Department of Neurology, Università degli Studi di Perugia, Umbria, Italy

³²⁰Broad Institute, Cambridge, MA USA

³²¹Department of Neurology, Memory Clinic, Bordeaux University Hospital, Bordeaux, France

³²²Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany

³²³Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK

³²⁴Hero DMC Heart Institute, Dayanand Medical College & Hospital, Ludhiana, India

³²⁵Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

³²⁶Tohoku Medical Megabank Organization, Sendai, Japan

³²⁷Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden

³²⁸ Krembil Brain Institute, University Health Network, Toronto, Ontario Canada

³²⁹ Department of Medicine and Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario Canada

³³⁰Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan

³³¹Department of Basic and Clinical Neurosciences, King’s College London, London, UK

³³²Departments of Neurology & Radiology, Landspitali National University Hospital, Reykjavik, Iceland

³³³Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany

³³⁴Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY USA

³³⁵Department of Medical Sciences, Uppsala University, Uppsala, Sweden

³³⁶Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

³³⁷Wellcome Trust Centre for Human Genetics, Oxford, UK

³³⁸BioBankJapan, Laboratory of Clinical Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan

³³⁹Department of Biostatistics, University of Liverpool, Liverpool, UK

³⁴⁰Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany

³⁴¹Department of Medicine I, Ludwig-Maximilians-Universität, Munich, Germany

³⁴²Translational Genomics Unit, Department of Oncology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy

³⁴³Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain

³⁴⁴Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addictions, Vall d’Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona,Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Spain

³⁴⁵National Institute for Health Research Comprehensive Biomedical Research Centre, Guy’s & St Thomas’ NHS Foundation Trust and King’s College London, London, UK

³⁴⁶School of Lifecourse and Population Sciences, King’s College London, London, UK

³⁴⁷Icelandic Heart Association, Reykjavik, Iceland

³⁴⁸Department of Epidemiology, University of Maryland School of Medicine, Baltimore, MD USA

³⁴⁹Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK

³⁵⁰IBE, Faculty of Medicine, LMU Munich, Munich, Germany

³⁵¹Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan

³⁵²Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

³⁵³Department of Neurology, Caen University Hospital, Caen, France

³⁵⁴University of Caen Normandy, Caen, France

³⁵⁵Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

³⁵⁶Landspitali University Hospital, Reykjavik, Iceland

³⁵⁷Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK USA

³⁵⁸Oklahoma Center for Neuroscience, Oklahoma City, OK USA

³⁵⁹IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain

³⁶⁰Department of Epidemiology and Medical Statistics, University of Ibadan, Ibadan, Nigeria

³⁶¹Institute of Cardiovascular Diseases, University of Ibadan, Ibadan, Nigeria

³⁶²Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

³⁶³Department of Medicine, University of Ghana Medical School, Accra, Ghana

³⁶⁴Department of Medicine, Ahmadu Bello University, Zaria, Nigeria

³⁶⁵Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria

³⁶⁶Jos University Teaching Hospital, Jos, Nigeria

³⁶⁷Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria

³⁶⁸Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria

³⁶⁹Medical University of South Carolina, Charleston, SC USA

³⁷⁰Department of Health Promotion and Education, University of Ibadan, Ibadan, Nigeria

³⁷¹Department of Radiology, College of Medicine, University of Ibadan, Ibadan, Nigeria

³⁷²China National Center For Food Safety Risk Assessment, Beijing, China

³⁷³Fuwai Hospital, Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases, Beijing, China

³⁷⁴Chinese Academy of Medical Sciences, Beijing, China

³⁷⁵Peking Union Medical College, Beijing, China

³⁷⁶Department of Public Policy, Institute of Medical Sciences, The University of Tokyo, Tokyo, Japan

³⁷⁷Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX USA

³⁷⁸Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany

³⁷⁹Department of Neurology, Haga Hospital, The Hague, The Netherlands

³⁸⁰Department of Neurology, Amphia Hospital, Breda, The Netherlands

³⁸¹Department of Neurology, Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands

³⁸²Department of Neurology, Rijnstate Hospital, Arnhem, The Netherlands

³⁸³Department of Neurology, Medisch spectrum Twente, Enschede, The Netherlands

³⁸⁴Department of Neurology, Catharina Hospital, Eindhoven, The Netherlands

³⁸⁵Department of Neurology, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands

³⁸⁶Department of Neurology, Catharina Wilhelmina Hospital, Nijmegen, The Netherlands

³⁸⁷Department of Neurology, Medisch Center Leeuwarden, Leeuwarden, The Netherlands

³⁸⁸Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

³⁸⁹Department of Human Genetics, University of Michigan, Ann Arbor, MI USA

³⁹⁰Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, MI USA

³⁹¹Stroke Unit, Department of Internal Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

³⁹²Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI USA

³⁹³Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA USA

³⁹⁴Department of General Practice, University of Oslo, Oslo, Norway

³⁹⁵Department of Neurology, Akershus University Hospital, Lørenskog, Norway

³⁹⁶BioCore—Bioinformatics Core Facility, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

³⁹⁷Clinic of Laboratory Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

³⁹⁸Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

³⁹⁹Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University Duisburg-Essen, Essen, Germany

⁴⁰⁰Department of Medicine I, University Hospital Würzburg, Würzburg, Germany

⁴⁰¹Stroke Unit, Department of Neurology, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

⁴⁰²Institute for Biomedical Research of Barcelona (IIBB), National Spanish Research Council (CSIC), Barcelona, Spain

⁴⁰³Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain

⁴⁰⁴Department of Neurology, Biocruces-Bizkaia Health Research Institute, Bilbao, Spain

⁴⁰⁵Stroke Unit, Department of Neurology, University Hospital of Valladolid, Valladolid, Spain

⁴⁰⁶Department of Neurology, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain

⁴⁰⁷Stroke Unit, Department of Neurology, Hospital Universitari Vall d’Hebron, Barcelona, Spain

⁴⁰⁸Department of Neurosciences, Hospital Germans Trias I Pujol, Universitat Autònoma de Barcelona, Barcelona, Spain

⁴⁰⁹Department of Neurology, University Hospital Central de Asturias (HUCA), Oviedo, Spain

⁴¹⁰Department of Neurology, Son Espases University Hospital, Illes Balears Health Research Institute (IdISBa), Palma, Spain

⁴¹¹Department of Neurology, University Hospital of Albacete, Albacete, Spain

⁴¹²High Content Genomics and Bioinformatics Unit, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain

⁴¹³The Copenhagen City Heart Study, Copenhagen University Hospital—Bispebjerg and Frederiksberg, Copenhagen, Denmark

⁴¹⁴Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

⁴¹⁵Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY USA

⁴¹⁶The Centre for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY USA

⁴¹⁷Department of Human Genetics, McGill University, Montreal, Quebec Canada

^✉

Corresponding author.

^#

Contributed equally.

PMCID: PMC9712088 PMID: 36376532

Correction to: Nature 10.1038/s41586-022-05165-3 Published online 30 September 2022

In the version of this article initially published, the name of the PRECISE4Q Consortium was misspelled as “PRECISEQ” and has now been amended in the HTML and PDF versions of the article. Further, data in the first column of Supplementary Table 55 were mistakenly shifted and have been corrected in the file accompanying the HTML version of the article.

Supplementary information

Supplementary Information^{(422.3KB, docx)}

Supplementary Methods, including a description of the GWAS of stroke-risk factors in Tohuku Medical Megabank and Calculation of candidate polygenic score models; description of study populations in the GIGASTROKE initiative; study-specific acknowledgements; information on other members of participating consortia; and Supplementary References.

Supplementary Tables^{(739.2KB, xlsx)}

Supplementary Tables 1–56.

Footnotes

A list of authors and their affiliations appears online.

These authors contributed equally: Aniket Mishra, Rainer Malik, Tsuyoshi Hachiya, Tuuli Jürgenson, Shinichi Namba, Daniel C. Posner

These authors jointly supervised this work: Christian T. Ruff, Mayowa O. Owolabi, Jennifer E. Huffman, Lili Milani, Yoichiro Kamatani, Martin Dichgans, Stephanie Debette

A list of authors and their affiliations appear online

Contributor Information

Martin Dichgans, Email: Martin.Dichgans@med.uni-muenchen.de.

Stephanie Debette, Email: stephanie.debette@u-bordeaux.fr.

The COMPASS Consortium:

Joshua C. Bis, Jin-Moo Lee, Yu-Ching Cheng, James F. Meschia, Wei Min Chen, Michèle M. Sale, Alan B. Zonderman, Michele K. Evans, James G. Wilson, Adolfo Correa, Matthew Traylor, Cathryn M. Lewis, Cara L. Carty, Alexander Reiner, Jeffrey Haessler, Carl D. Langefeld, Rebecca F. Gottesman, Kristine Yaffe, Yong Mei Liu, Charles Kooperberg, Leslie A. Lange, Karen L. Furie, Donna K. Arnett, Oscar R. Benavente, Raji P. Grewal, and Leema Reddy Peddareddygari

The INVENT Consortium:

Charles Kooperberg, Kristian Hveem, Sara Lindstrom, Lu Wang, Erin N. Smith, William Gordon, Astrid van Hylckama Vlieg, Mariza de Andrade, Jennifer A. Brody, Jack W. Pattee, Jeffrey Haessler, Ben M. Brumpton, Pierre Suchon, Ming-Huei Chen, Kelly A. Frazer, Constance Turman, Marine Germain, James MacDonald, Sigrid K. Braekkan, Sebastian M. Armasu, Nathan Pankratz, Rebecca D. Jackson, Jonas B. Nielsen, Franco Giulianini, Marja K. Puurunen, Manal Ibrahim, Susan R. Heckbert, Theo K. Bammler, Bryan M. McCauley, Kent D. Taylor, James S. Pankow, Alexander P. Reiner, Maiken E. Gabrielsen, Jean-François Deleuze, Chris J. O’Donnell, Jihye Kim, Barbara McKnight, Peter Kraft, John-Bjarne Hansen, Frits R. Rosendaal, John A. Heit, Weihong Tang, Pierre-Emmanuel Morange, Andrew D. Johnson, and Christopher Kabrhel

The Dutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study Group:

Ewoud J. van Dijk, Peter J. Koudstaal, Gert-Jan Luijckx, Paul J. Nederkoorn, Robert J. van Oostenbrugge, Marieke C. Visser, Marieke J. H. Wermer, and L. Jaap Kappelle

The Estonian Biobank:

Tõnu Esko, Andres Metspalu, Reedik Mägi, and Mari Nelis

The NINDS Stroke Genetics Network (SiGN):

Marguerite R. Irvin, Frank-Erik de Leeuw, Christopher R. Levi, Jane Maguire, Jordi Jiménez-Conde, Pankaj Sharma, Cathie L. M. Sudlow, Kristiina Rannikmäe, Reinhold Schmidt, Agnieszka Slowik, Joanna Pera, Vincent N. S. Thijs, Arne G. Lindgren, Andreea Ilinca, Olle Melander, Gunnar Engström, Kathryn M. Rexrode, Peter M. Rothwell, Tara M. Stanne, Julie A. Johnson, John Danesh, Adam S. Butterworth, Laura Heitsch, Giorgio B. Boncoraglio, Michiaki Kubo, Alessandro Pezzini, Arndt Rolfs, Anne-Katrin Giese, David Weir, Rebecca D. Jackson, Owen A. Ross, Robin Lemmons, Martin Soderholm, Mary Cushman, Katarina Jood, Caitrin W. McDonough, Steven Bell, Birgit Linkohr, Tsong-Hai Lee, and Jukka Putaala

The MEGASTROKE Consortium:

Christopher D. Anderson, Oscar L. Lopez, Xueqiu Jian, Ulf Schminke, Natalia Cullell, Pilar Delgado, Laura Ibañez, Jerzy Krupinski, Vasileios Lioutas, Koichi Matsuda, Joan Montaner, Elena Muiño, Jaume Roquer, Chloe Sarnowski, Naveed Sattar, Gerli Sibolt, Alexander Teumer, Loes Rutten-Jacobs, Masahiro Kanai, Anne-Katrin Giese, Solveig Gretarsdottir, Natalia S. Rost, Salim Yusuf, Peter Almgren, Hakan Ay, Steve Bevan, Robert D. Brown, Jr, Caty Carrera, Julie E. Buring, Wei-Min Chen, Ioana Cotlarciuc, Paul I. W. de Bakker, Anita L. DeStefano, Marcel den Hoed, Qing Duan, Stefan T. Engelter, Guido J. Falcone, Rebecca F. Gottesman, Stefan Gustafsson, Ahamad Hassan, Elizabeth G. Holliday, George Howard, Fang-Chi Hsu, Erik Ingelsson, Tamara B. Harris, Brett M. Kissela, Dawn O. Kleindorfer, Claudia Langenberg, Robin Lemmens, Didier Leys, Wei-Yu Lin, Erik Lorentzen, Patrik K. Magnusson, Patrick F. McArdle, Sara L. Pulit, Kenneth Rice, Saori Sakaue, Bishwa R. Sapkota, Christian Tanislav, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Christophe Tzourio, Cornelia M. van Duijn, Matthew Walters, Nicholas J. Wareham, Najaf Amin, Hugo J. Aparicio, John Attia, Alexa S. Beiser, Claudine Berr, Mariana Bustamante, Valeria Caso, Seung Hoan Choi, Ayesha Chowhan, Jean-François Dartigues, Hossein Delavaran, Marcus Dörr, Ian Ford, Wander S. Gurpreet, Anders Hamsten, Atsushi Hozawa, Martin Ingelsson, Motoki Iwasaki, Sara Kaffashian, Lalit Kalra, Olafur Kjartansson, Manja Kloss, Daniel L. Labovitz, Cathy C. Laurie, Linxin Li, Lars Lind, Cecilia M. Lindgren, Hirata Makoto, Naoko Minegishi, Andrew P. Morris, Martina Müller-Nurasyid, Bo Norrving, Soichi Ogishima, Eugenio A. Parati, Nancy L. Pedersen, Markus Perola, Pekka Jousilahti, Silvana Pileggi, Raquel Rabionet, Iolanda Riba-Llena, Marta Ribasés, Jose R. Romero, Anthony G. Rudd, Antti-Pekka Sarin, Ralhan Sarju, Mamoru Satoh, Norie Sawada, Ásgeir Sigurdsson, Albert Smith, O. Colin Stine, David J. Stott, Konstantin Strauch, Takako Takai, Hideo Tanaka, Emmanuel Touze, Shoichiro Tsugane, Andre G. Uitterlinden, Einar M. Valdimarsson, Sven J. van der Lee, Kenji Wakai, Stephen R. Williams, Charles D. A. Wolfe, Quenna Wong, Taiki Yamaji, Dharambir K. Sanghera, Kari Stefansson, Kent D. Taylor, Nicolas Martinez-Majander, Kenji Sobue, Carolina Soriano-Tárraga, and Henry Völzke

The SIREN Consortium:

Onoja Akpa, Fred S. Sarfo, Albert Akpalu, Reginald Obiako, Kolawole Wahab, Godwin Osaigbovo, Lukman Owolabi, Morenikeji Komolafe, Carolyn Jenkins, Oyedunni Arulogun, Godwin Ogbole, Abiodun M. Adeoye, Joshua Akinyemi, Atinuke Agunloye, Adekunle G. Fakunle, Ezinne Uvere, Abimbola Olalere, and Olayinka J. Adebajo

The China Kadoorie Biobank Collaborative Group:

Junshi Chen, Robert Clarke, Rory Collins, Yu Guo, Chen Wang, Jun Lv, Richard Peto, Yiping Chen, Zammy Fairhurst-Hunter, Michael Hill, Alfred Pozarickij, Dan Schmidt, Becky Stevens, Iain Turnbull, and Canqing Yu

The International Stroke Genetics Consortium (ISGC):

Quentin Le Grand and Leslie E. Ferreira

The Biobank Japan:

Akiko Nagai and Yoishinori Murakami

The CHARGE Consortium:

Mirjam I. Geerlings, Natalie C. Gasca, Vilmundur Gudnason, Marion van Vugt, Rebecca F. Gottesman, Eric J. Shiroma, Sigurdur Sigurdsson, Mohsen Ghanbari, Eric Boerwinkle, Alexa S. Beiser, Bernard Fongang, Ruiqi Wang, Mohammad K. Ikram, and Uwe Völker

The GIGASTROKE Consortium:

Phil L. de Jager, Rafael de Cid, Børge G. Nordestgaard, Muralidharan Sargurupremraj, and Shefali S. Verma

Supplementary information

The online version contains supplementary material available at 10.1038/s41586-022-05492-5.

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

Supplementary Information^{(422.3KB, docx)}

Supplementary Methods, including a description of the GWAS of stroke-risk factors in Tohuku Medical Megabank and Calculation of candidate polygenic score models; description of study populations in the GIGASTROKE initiative; study-specific acknowledgements; information on other members of participating consortia; and Supplementary References.

Supplementary Tables^{(739.2KB, xlsx)}

Supplementary Tables 1–56.

PERMALINK

Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries

Aniket Mishra

Rainer Malik

Tsuyoshi Hachiya

Tuuli Jürgenson

Shinichi Namba

Daniel C Posner

Frederick K Kamanu

Masaru Koido

Quentin Le Grand

Mingyang Shi

Yunye He

Marios K Georgakis

Ilana Caro

Kristi Krebs

Yi-Ching Liaw

Felix C Vaura

Kuang Lin

Bendik Slagsvold Winsvold

Vinodh Srinivasasainagendra

Livia Parodi

Hee-Joon Bae

Ganesh Chauhan

Michael R Chong

Liisa Tomppo

Rufus Akinyemi

Gennady V Roshchupkin

Naomi Habib

Yon Ho Jee

Jesper Qvist Thomassen

Vida Abedi

Jara Cárcel-Márquez

Marianne Nygaard

Hampton L Leonard

Chaojie Yang

Ekaterina Yonova-Doing

Maria J Knol

Adam J Lewis

Renae L Judy

Tetsuro Ago

Philippe Amouyel

Nicole D Armstrong

Mark K Bakker

Traci M Bartz

David A Bennett

Joshua C Bis

Constance Bordes

Sigrid Børte

Anael Cain

Paul M Ridker

Kelly Cho

Zhengming Chen

Carlos Cruchaga

John W Cole

Phil L de Jager

Rafael de Cid

Matthias Endres

Leslie E Ferreira

Mirjam I Geerlings

Natalie C Gasca

Vilmundur Gudnason

Jun Hata

Jing He

Alicia K Heath

Yuk-Lam Ho

Aki S Havulinna

Jemma C Hopewell

Hyacinth I Hyacinth

Michael Inouye

Mina A Jacob

Christina E Jeon

Christina Jern

Masahiro Kamouchi

Keith L Keene

Takanari Kitazono

Steven J Kittner

Takahiro Konuma

Amit Kumar

Paul Lacaze