Figure 7. Suppression of Slc38a5 modulates growth factor receptors including vascular endothelial growth factor receptor 1 (VEGFR1) and VEGFR2.

Human retinal microvascular endothelial cells were transfected with siRNA targeting SLC38A5 (si-SLC38A5) or control siRNA (si-Ctrl) for 72 hr and collected for RT-qPCR or Western blots. (A) mRNA levels of growth factor receptors and signaling molecules were normalized by expression of 18 S (n=3–6/group). (B) Western Blots show protein levels of VEGFR1 and VEGFR2 with Si-SLC38A5 or si-Ctrl treatment. Data are shown as mean ± SEM; n=3/group. **p≤0.01; ***p≤0.001.